MYST Histone Acetyltransferase 4 (MYST4)

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MORF; MOZ2; QKF; Querkopf; KAT6B; MOZ-Related Factor; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; Monocytic leukemia zinc finger protein-related factor

MYST Histone Acetyltransferase 4 (MYST4)
MORF is a 1,781-residue protein that is ubiquitously expressed in adult human tissues. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at its C terminus, and may be involved in both positive and negative regulation of transcription.Genomic analyses revealed that the breaks were close to Alu elements in intron 16 of MORF and intron 2 of CBP and that duplications had occurred near the breakpoints.
The authors constructed an exon/intron map of the MORF gene. The MORF-CBP protein retained the zinc fingers, 2 nuclear localization signals, the histone acetyltransferase (HAT) domain, a portion of the acidic domain of MORF, and the CBP protein downstream of codon 29.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant MYST Histone Acetyltransferase 4 (MYST4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to MYST Histone Acetyltransferase 4 (MYST4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to MYST Histone Acetyltransferase 4 (MYST4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for MYST Histone Acetyltransferase 4 (MYST4)CLIA Kit Customized Service Offer
n/aELISA Kit for MYST Histone Acetyltransferase 4 (MYST4)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant MYST Histone Acetyltransferase 4 (MYST4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to MYST Histone Acetyltransferase 4 (MYST4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to MYST Histone Acetyltransferase 4 (MYST4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for MYST Histone Acetyltransferase 4 (MYST4)CLIA Kit Customized Service Offer
n/aELISA Kit for MYST Histone Acetyltransferase 4 (MYST4)ELISA Kit Customized Service Offer
  1. "Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein."J. Biol. Chem. 274:28528-28536(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)."Hum. Mol. Genet. 10:395-404(2001) [PubMed] [Europe PMC] [Abstract]
  6. "MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2."Oncogene 21:2729-2740(2002) [PubMed] [Europe PMC] [Abstract]
  7. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes."Mol. Cell. Biol. 28:6828-6843(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome." Am. J. Hum. Genet. 89:675-681(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in KAT6B, encoding a histone acetyltransferase, cause Genitopatellar syndrome." Am. J. Hum. Genet. 90:282-289(2012) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]