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MIND Kinetochore Complex Component Homolog (NSL1)

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DC8; MIS14; C1orf48; Kinetochore-associated protein NSL1 homolog

MIND Kinetochore Complex Component Homolog (NSL1)
CCC L971
HGNC 24548
MGI 2685830
PubMed 15502821
RGD 1590586
UniProt Q96IY1
Wiki NSL1
NSL1 encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.MIS12 RNA interference (RNAi) abolished the kinetochore localization of DC8, C20ORF127, and ZWINT, and double RNAi against HP1-alpha and HP1-gamma (CBX3) abolished the kinetochore localization of MIS12 and DC8.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MIND Kinetochore Complex Component Homolog (NSL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MIND Kinetochore Complex Component Homolog (NSL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MIND Kinetochore Complex Component Homolog (NSL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MIND Kinetochore Complex Component Homolog (NSL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MIND Kinetochore Complex Component Homolog (NSL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MIND Kinetochore Complex Component Homolog (NSL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MIND Kinetochore Complex Component Homolog (NSL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MIND Kinetochore Complex Component Homolog (NSL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MIND Kinetochore Complex Component Homolog (NSL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MIND Kinetochore Complex Component Homolog (NSL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MIND Kinetochore Complex Component Homolog (NSL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MIND Kinetochore Complex Component Homolog (NSL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MIND Kinetochore Complex Component Homolog (NSL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MIND Kinetochore Complex Component Homolog (NSL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MIND Kinetochore Complex Component Homolog (NSL1) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1."Nat. Cell Biol. 6:1135-1141(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation."J. Cell Biol. 173:9-17(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1."Dev. Cell 13:663-676(2007) [PubMed] [Europe PMC] [Abstract]
  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]