Postmeiotic Segregation Increased Protein 1 (PMS1)

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HNPCC3; PMSL1; hPMS1; DNA mismatch repair protein PMS1

Postmeiotic Segregation Increased Protein 1 (PMS1)
PMS1 was identified by its homology to a yeast protein involved in DNA mismatch repair. A role for this protein in mismatch repair has not been proven. However, the protein forms heterodimers with MLH1, a DNA mismatch repair protein, and some cases of hereditary nonpolyposis colorectal cancer have been found to have mutations in this gene.
Sequence analysis of human PMS1 cDNA identified an open reading frame (ORF) of 2,795 bp thought to encode a 932-residue protein with 27% identity to yeast PMS1. Sequence analysis of the human PMS2 clone identified a 2,586-bp ORF thought to encode an 862-residue protein with 32% identity to yeast PMS1.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Postmeiotic Segregation Increased Protein 1 (PMS1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Postmeiotic Segregation Increased Protein 1 (PMS1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Postmeiotic Segregation Increased Protein 1 (PMS1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Postmeiotic Segregation Increased Protein 1 (PMS1)CLIA Kit Customized Service Offer
n/aELISA Kit for Postmeiotic Segregation Increased Protein 1 (PMS1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Postmeiotic Segregation Increased Protein 1 (PMS1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Postmeiotic Segregation Increased Protein 1 (PMS1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Postmeiotic Segregation Increased Protein 1 (PMS1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Postmeiotic Segregation Increased Protein 1 (PMS1)CLIA Kit Customized Service Offer
n/aELISA Kit for Postmeiotic Segregation Increased Protein 1 (PMS1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Postmeiotic Segregation Increased Protein 1 (PMS1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Postmeiotic Segregation Increased Protein 1 (PMS1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Postmeiotic Segregation Increased Protein 1 (PMS1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Postmeiotic Segregation Increased Protein 1 (PMS1)CLIA Kit Customized Service Offer
n/aELISA Kit for Postmeiotic Segregation Increased Protein 1 (PMS1)ELISA Kit Customized Service Offer
  1. "Mutations of two PMS homologues in hereditary nonpolyposis colon cancer."Nature 371:75-80(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of a second MutL DNA mismatch repair complex (hPMS1 and hMLH1) in human epithelial cells."J. Biol. Chem. 275:15728-15732(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Solution structure of the HMG domain of human DNA mismatch repair protein."Submitted (NOV-2005) to the PDB data bank
  8. "Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer."Hum. Genet. 105:79-85(1999) [PubMed] [Europe PMC] [Abstract]