POU Domain Class 6 Transcription Factor 2 (POU6F2)

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RPF-1; Retina-Derived POU-Domain Factor-1

POU Domain Class 6 Transcription Factor 2 (POU6F2)
POU6F2 encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.POU6F2 gene contains at least 10 exons and encompasses over 125 kb. Sequence analysis revealed 4 positions at which alternate splicing occurs, potentially generating multiple transcripts.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant POU Domain Class 6 Transcription Factor 2 (POU6F2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to POU Domain Class 6 Transcription Factor 2 (POU6F2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to POU Domain Class 6 Transcription Factor 2 (POU6F2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for POU Domain Class 6 Transcription Factor 2 (POU6F2)CLIA Kit Customized Service Offer
n/aELISA Kit for POU Domain Class 6 Transcription Factor 2 (POU6F2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant POU Domain Class 6 Transcription Factor 2 (POU6F2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to POU Domain Class 6 Transcription Factor 2 (POU6F2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to POU Domain Class 6 Transcription Factor 2 (POU6F2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for POU Domain Class 6 Transcription Factor 2 (POU6F2)CLIA Kit Customized Service Offer
n/aELISA Kit for POU Domain Class 6 Transcription Factor 2 (POU6F2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant POU Domain Class 6 Transcription Factor 2 (POU6F2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to POU Domain Class 6 Transcription Factor 2 (POU6F2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to POU Domain Class 6 Transcription Factor 2 (POU6F2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for POU Domain Class 6 Transcription Factor 2 (POU6F2)CLIA Kit Customized Service Offer
n/aELISA Kit for POU Domain Class 6 Transcription Factor 2 (POU6F2)ELISA Kit Customized Service Offer
  1. "Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells."J. Neurosci. 16:2261-2274(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Refinement within single yeast artificial chromosome clones of a minimal region commonly deleted on the short arm of chromosome 7 in Wilms tumours."Genes Chromosomes Cancer 31:42-47(2001) [PubMed] [Europe PMC] [Abstract]