SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)

[Edit]

HARP; HHARP; HepA-Related Protein; ATP-Driven Annealing Helicase; Sucrose nonfermenting protein 2-like 1

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)
SMARCAL1 is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. HARP bound with higher affinity to forked DNA than to single-stranded DNA (sDNA) or double-stranded DNA (dsDNA). HARP had ATPase activity that was stimulated by forked DNA, and to a lesser extent by ssDNA and dsDNA.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)CLIA Kit Customized Service Offer
n/aELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)CLIA Kit Customized Service Offer
n/aELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)CLIA Kit Customized Service Offer
n/aELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like Protein (SMARCAL1)ELISA Kit Customized Service Offer
  1. "Cloning and characterization of HARP/SMARCAL1: a prokaryotic HepA-related SNF2 helicase protein from human and mouse."Genomics 65:274-282(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia." Nat. Genet. 30:215-220(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA."Genes Dev. 23:2400-2404(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks."Genes Dev. 23:2405-2414(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart."Genes Dev. 23:2415-2425(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  16. "HARP is an ATP-driven annealing helicase."Science 322:748-750(2008) [PubMed] [Europe PMC] [Abstract]