SNF2 Related CREBBP Activator Protein (SRCAP)

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EAF1; SWR1; DOMO1; Swi2/Snf2-Related ATPase Homolog; Domino Homolog 1; Helicase SRCAP

SNF2 Related CREBBP Activator Protein (SRCAP)
SRCAP increased transcription of a reporter plasmid when it was cotransfected with the transcription activation domain of CBP. Endogenous SRCAP immunoprecipitated from nuclear extracts of a human lung epithelial cell line had ATPase activity, and the C-terminal half of SRCAP enhanced the ability of CBP to activate transcription. Adenovirus protein E1A blocked the ability of CBP to function as a coactivator for a number of transcription factors. The deduced 2,971-amino acid protein has a calculated molecular mass of 315 kD. It has a highly charged N-terminal domain, a central CBP-binding domain, a second charged domain, and a putative C-terminal DNA-binding domain. A complete ATPase domain, consisting of 7 highly conserved regions, are dispersed over the length of the protein.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant SNF2 Related CREBBP Activator Protein (SRCAP)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for SNF2 Related CREBBP Activator Protein (SRCAP)CLIA Kit Customized Service Offer
n/aELISA Kit for SNF2 Related CREBBP Activator Protein (SRCAP)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant SNF2 Related CREBBP Activator Protein (SRCAP)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for SNF2 Related CREBBP Activator Protein (SRCAP)CLIA Kit Customized Service Offer
n/aELISA Kit for SNF2 Related CREBBP Activator Protein (SRCAP)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant SNF2 Related CREBBP Activator Protein (SRCAP)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for SNF2 Related CREBBP Activator Protein (SRCAP)CLIA Kit Customized Service Offer
n/aELISA Kit for SNF2 Related CREBBP Activator Protein (SRCAP)ELISA Kit Customized Service Offer
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  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome." Am. J. Hum. Genet. 90:308-313(2012) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]