PDZ Domain Containing Protein 3 (PDZD3)

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PDZK2; NHERF4; IKEPP; PDZ Domain Containing 2; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; Sodium-hydrogen exchanger regulatory factor 4

PDZ Domain Containing Protein 3 (PDZD3)
IKEPP is most closely related to PDZK1 and shares 77% sequence identity with the mouse type IIa sodium/inorganic phosphate cotransporter (SLC34A1)-associated protein. Northern blot analysis revealed expression of 2.3- and 2.5-kb IKEPP transcripts at high levels in kidney, with lower levels in intestine and colon and no expression in other tissues. mRNA Dot blot analysis of multiple gastrointestinal tissues detected IKEPP expression along the entire gastrointestinal tract, from the duodenum to the colon.
Immunolocalization studies using colon carcinoma and adenocarcinoma cells showed that IKEPP preferentially accumulates in the subapical compartment and at the apical membrane.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant PDZ Domain Containing Protein 3 (PDZD3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to PDZ Domain Containing Protein 3 (PDZD3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to PDZ Domain Containing Protein 3 (PDZD3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for PDZ Domain Containing Protein 3 (PDZD3)CLIA Kit Customized Service Offer
n/aELISA Kit for PDZ Domain Containing Protein 3 (PDZD3)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant PDZ Domain Containing Protein 3 (PDZD3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to PDZ Domain Containing Protein 3 (PDZD3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to PDZ Domain Containing Protein 3 (PDZD3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for PDZ Domain Containing Protein 3 (PDZD3)CLIA Kit Customized Service Offer
n/aELISA Kit for PDZ Domain Containing Protein 3 (PDZD3)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant PDZ Domain Containing Protein 3 (PDZD3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to PDZ Domain Containing Protein 3 (PDZD3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to PDZ Domain Containing Protein 3 (PDZD3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for PDZ Domain Containing Protein 3 (PDZD3)CLIA Kit Customized Service Offer
n/aELISA Kit for PDZ Domain Containing Protein 3 (PDZD3)ELISA Kit Customized Service Offer
  1. "A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor."J. Biol. Chem. 277:22934-22941(2002) [PubMed] [Europe PMC] [Abstract] and Kidney.
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism."Cell. Physiol. Biochem. 22:693-704(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Crystal structure of the 3rd PDZ domain of intestine- and kidney-enriched PDZ domain IKEPP (PDZD3)."Submitted (JUL-2011) to the PDB data bank