Solute Carrier Family 30, Member 10 (SLC30A10)

[Edit]

ZnT-10; ZRC1; ZNT8; Zinc Transporter 8

Solute Carrier Family 30, Member 10 (SLC30A10)
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A10, permit cellular efflux of zinc.
By searching databases with ZNT sequences, Seve et al. (2004) identified SLC30A10, which they called ZNT10. The deduced protein has a calculated molecular mass of 52.7 kD. It has 6 transmembrane helices, a basic region between helices 4 and 5, and cytoplasmic N and C termini. EST database analysis showed evidence of SLC30A10 expression only in fetal brain and fetal liver.Seve et al. (2004) determined that the SLC30A10 gene contains 4 exons and spans 15 kb.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Solute Carrier Family 30, Member 10 (SLC30A10)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Solute Carrier Family 30, Member 10 (SLC30A10)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Solute Carrier Family 30, Member 10 (SLC30A10)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Solute Carrier Family 30, Member 10 (SLC30A10)CLIA Kit Customized Service Offer
n/aELISA Kit for Solute Carrier Family 30, Member 10 (SLC30A10)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPN188Mu01Recombinant Solute Carrier Family 30, Member 10 (SLC30A10)SDS-PAGE; WB; ELISA; IP.
RPN188Mu02Recombinant Solute Carrier Family 30, Member 10 (SLC30A10)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAN188Mu01Polyclonal Antibody to Solute Carrier Family 30, Member 10 (SLC30A10)WB, ICC, IHC-P, IHC-F, ELISA
PAN188Mu02Polyclonal Antibody to Solute Carrier Family 30, Member 10 (SLC30A10)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEN188MuELISA Kit for Solute Carrier Family 30, Member 10 (SLC30A10)Enzyme-linked immunosorbent assay

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Solute Carrier Family 30, Member 10 (SLC30A10)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Solute Carrier Family 30, Member 10 (SLC30A10)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Solute Carrier Family 30, Member 10 (SLC30A10)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Solute Carrier Family 30, Member 10 (SLC30A10)CLIA Kit Customized Service Offer
n/aELISA Kit for Solute Carrier Family 30, Member 10 (SLC30A10)ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression."BMC Genomics 5:32-32(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man."Am. J. Hum. Genet. 90:457-466(2012) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease."Am. J. Hum. Genet. 90:467-477(2012) [PubMed] [Europe PMC] [Abstract]