Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)

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PPAPDC2; Phosphatidic Acid Phosphatase Type 2 Domain Containing 2

Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)
PPAPDC2 contains 6 predicted membrane-spanning domains and 3 conserved lipid phosphate phosphatase motifs. RT-PCR detected expression in both human polymorphonuclear leukocytes and HEK293 cells. Dot-blot analysis of human tissues detected strong expression in pancreas, placenta, spleen, liver, kidney, colon, pituitary gland, and thymus, and moderate to low expression in duodenum, whole brain, stomach, esophagus, lung, testis, and heart. Semiquantitative RT-PCR detected PPAPDC2 expression in PMN leukocytes at 60% of levels in liver.PPAPDC2 activity was optimal at pH 7.0 and 8.0 and was independent of divalent cations. Thin-layer chromatography using C14-labeled substrates showed that PPAPDC2 catalyzed dephosphorylation of PSDP to presqualene monophosphate but not PSMP to presqualene alcohol.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)CLIA Kit Customized Service Offer
n/aELISA Kit for Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)CLIA Kit Customized Service Offer
n/aELISA Kit for Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)CLIA Kit Customized Service Offer
n/aELISA Kit for Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and functional characterization of a presqualene diphosphate phosphatase."J. Biol. Chem. 281:9490-9497(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]