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NLR Family, Pyrin Domain Containing Protein 7 (NLRP7)

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NALP7; PYPAF3; NOD12; PAN7; CLR19.4; Nucleotide-Binding Oligomerization Domain,Leucine Rich Repeat And Pyrin Domain Containing 7; PYRIN-containing APAF1-like 3

NLR Family, Pyrin Domain Containing Protein 7 (NLRP7)
CCC N497
HGNC 22947
PubMed 24105472
UniProt Q8WX94
Wiki NLRP7
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.
Only NALP7 variant-1, which encodes a protein with PYD, NACHT, NAD, and LRR domains, was upregulated in seminomas. Northern blot analysis using a probe common to all 3 variants detected a 3.3-kb transcript in testis only. Immunoblot analysis showed expression in an embryonal carcinoma line. Immunohistochemistry demonstrated high expression in seminomas and weak expression in normal testicular germ cells

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NLR Family, Pyrin Domain Containing Protein 7 (NLRP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 7 (NLRP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 7 (NLRP7) Polyclonal Antibody Customized Service Offer
Assay Kits SEN497Hu ELISA Kit for NLR Family, Pyrin Domain Containing Protein 7 (NLRP7) Enzyme-linked immunosorbent assay for Antigen Detection.
HEN497Hu High Sensitive ELISA Kit for NLR Family, Pyrin Domain Containing Protein 7 (NLRP7) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing."J. Biol. Chem. 277:29874-29880(2002) [PubMed] [Europe PMC] [Abstract]
  2. "NALPs: a novel protein family involved in inflammation."Nat. Rev. Mol. Cell Biol. 4:95-104(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "NODs: intracellular proteins involved in inflammation and apoptosis."Nat. Rev. Immunol. 3:371-382(2003) [PubMed] [Europe PMC] [Abstract]
  6. "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion."J. Biol. Chem. 280:21720-21725(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Three-dimensional structure of the NLRP7 pyrin domain: insight into pyrin-pyrin-mediated effector domain signaling in innate immunity."J. Biol. Chem. 285:27402-27410(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans."Nat. Genet. 38:300-302(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region."J. Med. Genet. 46:569-575(2009) [PubMed] [Europe PMC] [Abstract]