Prickle Homolog 1 (PRICKLE1)

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EPM1B; RILP; REST/NRSF-interacting LIM domain protein 1

Prickle Homolog 1 (PRICKLE1)
PRICKLE1 encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. The deduced 831-amino acid protein contains 3 N-terminal LIM domains and 3 C-terminal nuclear localization signals. It also contains 4 N-glycosylation sites, 2 PKA phosphorylation sites, and a C-terminal CIIS (cys-ile-ile-ser) prenylation motif. Northern blot analysis detected a single 4.4-kb transcript in all tissues examined, with the highest level in placenta.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Prickle Homolog 1 (PRICKLE1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Prickle Homolog 1 (PRICKLE1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Prickle Homolog 1 (PRICKLE1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Prickle Homolog 1 (PRICKLE1)CLIA Kit Customized Service Offer
n/aELISA Kit for Prickle Homolog 1 (PRICKLE1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Prickle Homolog 1 (PRICKLE1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Prickle Homolog 1 (PRICKLE1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Prickle Homolog 1 (PRICKLE1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Prickle Homolog 1 (PRICKLE1)CLIA Kit Customized Service Offer
n/aELISA Kit for Prickle Homolog 1 (PRICKLE1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Prickle Homolog 1 (PRICKLE1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Prickle Homolog 1 (PRICKLE1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Prickle Homolog 1 (PRICKLE1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Prickle Homolog 1 (PRICKLE1)CLIA Kit Customized Service Offer
n/aELISA Kit for Prickle Homolog 1 (PRICKLE1)ELISA Kit Customized Service Offer
  1. "REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor."Mol. Cell. Biol. 23:9025-9031(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle."Int. J. Mol. Med. 11:249-256(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Towards complete sets of farnesylated and geranylgeranylated proteins."PLoS Comput. Biol. 3:634-648(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome." Am. J. Hum. Genet. 83:572-581(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and characterization of novel rare mutations in the planar cell polarity gene PRICKLE1 in human neural tube defects."Hum. Mutat. 32:1371-1375(2011) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in prickle orthologs cause seizures in flies, mice, and humans." Am. J. Hum. Genet. 88:138-149(2011) [PubMed] [Europe PMC] [Abstract]