R-Spondin 4 (RSPO4)

[Edit]

C20orf182; Roof plate-specific spondin-4

R-Spondin 4 (RSPO4)
RSPO4encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.
The 224-amino acid human RSPO4 protein, like other members of the RSPO family, contains an N-terminal signal peptide, 2 furin-like domains, a thrombospondin type-1 (THBS1) domain, and a C-terminal low-complexity region enriched with positively charged amino acids. Dot blot analysis revealed very weak expression of RSPO4 in adult organs and tumors.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant R-Spondin 4 (RSPO4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to R-Spondin 4 (RSPO4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to R-Spondin 4 (RSPO4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for R-Spondin 4 (RSPO4)CLIA Kit Customized Service Offer
n/aELISA Kit for R-Spondin 4 (RSPO4)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant R-Spondin 4 (RSPO4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to R-Spondin 4 (RSPO4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to R-Spondin 4 (RSPO4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for R-Spondin 4 (RSPO4)CLIA Kit Customized Service Offer
n/aELISA Kit for R-Spondin 4 (RSPO4)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant R-Spondin 4 (RSPO4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to R-Spondin 4 (RSPO4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to R-Spondin 4 (RSPO4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for R-Spondin 4 (RSPO4)CLIA Kit Customized Service Offer
n/aELISA Kit for R-Spondin 4 (RSPO4)ELISA Kit Customized Service Offer
  1. "R-spondin proteins: a novel link to beta-catenin activation."Cell Cycle 5:23-26(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  5. "LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling."EMBO Rep. 12:1055-1061(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling."Nature 476:293-297(2011) [PubMed] [Europe PMC] [Abstract]
  7. "The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia."Nat. Genet. 38:1245-1247(2006) [PubMed] [Europe PMC] [Abstract]