Zinc Finger Protein 217 (ZNF217)
ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction as well as from doxorubicin-induced DNA damage, and that silencing ZNF217 with siRNA restored sensitivity to doxorubicin. Elevated ZNF217 led to increased phosphorylation of Akt1, whereas inhibition of the phosphatidylinositol-3 kinase pathway and Akt phosphorylation decreased ZNF217 protein levels and increased sensitivity to doxorubicin. ZNF217 may promote neoplastic transformation by increasing cell survival during telomeric crisis, and may promote later stages of malignancy by increasing cell survival during chemotherapy.ZNF217 was found to be centrally located in the 260-kb common region of amplification, transcribed in multiple normal tissues, and overexpressed in all cell lines and tumors in which it was amplified.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Zinc Finger Protein 217 (ZNF217)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Zinc Finger Protein 217 (ZNF217)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Zinc Finger Protein 217 (ZNF217)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Zinc Finger Protein 217 (ZNF217)CLIA Kit Customized Service Offer
n/aELISA Kit for Zinc Finger Protein 217 (ZNF217)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Zinc Finger Protein 217 (ZNF217)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Zinc Finger Protein 217 (ZNF217)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Zinc Finger Protein 217 (ZNF217)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Zinc Finger Protein 217 (ZNF217)CLIA Kit Customized Service Offer
n/aELISA Kit for Zinc Finger Protein 217 (ZNF217)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Zinc Finger Protein 217 (ZNF217)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Zinc Finger Protein 217 (ZNF217)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Zinc Finger Protein 217 (ZNF217)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Zinc Finger Protein 217 (ZNF217)CLIA Kit Customized Service Offer
n/aELISA Kit for Zinc Finger Protein 217 (ZNF217)ELISA Kit Customized Service Offer
  1. "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma." Proc. Natl. Acad. Sci. U.S.A. 95:8703-8708(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]
  5. "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction."Hum. Mol. Genet. 14:3219-3225(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays."J. Biol. Chem. 282:9703-9712(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex."Mol. Cell. Biol. 28:6066-6077(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins."Mol. Cell. Biol. 26:8159-8172(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]