Zinc finger protein 203 (ZNF203)

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ZIC3; HTX1; Zic Family Member 3; Heterotaxy 1; Zinc finger protein of the cerebellum 3

Zinc finger protein 203 (ZNF203)
ZIC3 encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. Clones corresponding to the ZIC3 gene were isolated from a human differentiated teratocarcinoma cDNA library. The deduced 467-residue protein shows 98% amino acid similarity to the mouse protein.Zic3 expression occurred in the primitive streak as early as embryonic day 7.0 and in structures in which malformations occasionally arise among human males with situs ambiguus. All of the Zic proteins contain 5 C2H2 zinc fingers within a domain that shows homology with the Drosophila pair-rule gene, 'odd paired' (opa).

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Zinc finger protein 203 (ZNF203)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Zinc finger protein 203 (ZNF203)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Zinc finger protein 203 (ZNF203)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Zinc finger protein 203 (ZNF203)CLIA Kit Customized Service Offer
n/aELISA Kit for Zinc finger protein 203 (ZNF203)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Zinc finger protein 203 (ZNF203)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Zinc finger protein 203 (ZNF203)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Zinc finger protein 203 (ZNF203)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Zinc finger protein 203 (ZNF203)CLIA Kit Customized Service Offer
n/aELISA Kit for Zinc finger protein 203 (ZNF203)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Zinc finger protein 203 (ZNF203)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Zinc finger protein 203 (ZNF203)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Zinc finger protein 203 (ZNF203)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Zinc finger protein 203 (ZNF203)CLIA Kit Customized Service Offer
n/aELISA Kit for Zinc finger protein 203 (ZNF203)ELISA Kit Customized Service Offer
  1. "X-linked situs abnormalities result from mutations in ZIC3."Nat. Genet. 17:305-308(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment."PLoS Genet. 5:E1000397-E1000397(2009) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the interactions of human ZIC3 mutants with GLI3."Hum. Mutat. 29:99-105(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a novel ZIC3 isoform and mutation screening in patients with heterotaxy and congenital heart disease."PLoS ONE 6:E23755-E23755(2011) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain."Hum. Mol. Genet. 17:3459-3473(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects."Am. J. Hum. Genet. 74:93-105(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domain."Hum. Mutat. 28:563-570(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Polyalanine expansion in the ZIC3 gene leading to X-linked heterotaxy with VACTERL association: a new polyalanine disorder?"J. Med. Genet. 47:351-355(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Genetic and functional analyses of ZIC3 variants in congenital heart disease."Hum. Mutat. 35:66-75(2014) [PubMed] [Europe PMC] [Abstract]