V-Ski Sarcoma Viral Oncogene Homolog (SKI)

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Proto-oncogene c-Ski

V-Ski Sarcoma Viral Oncogene Homolog (SKI)
SKI encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. The structure revealed specific recognition of the SMAD4 L3 loop region by a highly conserved interaction loop (I loop) from SKI.Indeed, SKI disrupted the formation of a functional complex between the comediator SMADs (Co-SMADs) and R-SMADs, explaining how it could lead to repression of TGF-beta, activin, and bone morphogenetic protein responses. The structure of the SKI fragment, stabilized by a bound zinc atom, resembled the SAND domain found in transcription factors and other nuclear proteins, in which the corresponding I loop is responsible for DNA binding.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant V-Ski Sarcoma Viral Oncogene Homolog (SKI)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to V-Ski Sarcoma Viral Oncogene Homolog (SKI)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to V-Ski Sarcoma Viral Oncogene Homolog (SKI)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for V-Ski Sarcoma Viral Oncogene Homolog (SKI)CLIA Kit Customized Service Offer
n/aELISA Kit for V-Ski Sarcoma Viral Oncogene Homolog (SKI)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant V-Ski Sarcoma Viral Oncogene Homolog (SKI)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to V-Ski Sarcoma Viral Oncogene Homolog (SKI)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to V-Ski Sarcoma Viral Oncogene Homolog (SKI)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for V-Ski Sarcoma Viral Oncogene Homolog (SKI)CLIA Kit Customized Service Offer
n/aELISA Kit for V-Ski Sarcoma Viral Oncogene Homolog (SKI)ELISA Kit Customized Service Offer
  1. "Isolation of human cDNA clones of ski and the ski-related gene, sno."Nucleic Acids Res. 17:5489-5500(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation."J. Biol. Chem. 278:38998-39005(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  5. "SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells."J. Biol. Chem. 284:3334-3344(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "In-frame mutations in exon 1 of SKI cause dominant Shprintzen-Goldberg syndrome." Am. J. Hum. Genet. 91:950-957(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in the TGF-beta repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm." Nat. Genet. 44:1249-1254(2012) [PubMed] [Europe PMC] [Abstract]
  9. "De novo exon 1 missense mutations of SKI and Shprintzen-Goldberg syndrome: two new cases and a clinical review."Am. J. Med. Genet. A 164A:676-684(2014) [PubMed] [Europe PMC] [Abstract]
  10. "The SMAD-binding domain of SKI: a hotspot for de novo mutations causing Shprintzen-Goldberg syndrome." Eur. J. Hum. Genet. 23:224-228(2015) [PubMed] [Europe PMC] [Abstract]