Keratin 86 (KRT86)

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KRTHB6; MNX; Hb6; K86; Hard Keratin Type II 6; Keratin, type II cuticular Hb6; Hair keratin K2.11

Keratin 86 (KRT86)
KRT86 is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.The HB6 gene has 9 exons and spans about 7.1 kb from the translational initiation ATG codon to the poly(A) site.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Keratin 86 (KRT86)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Keratin 86 (KRT86)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Keratin 86 (KRT86)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Keratin 86 (KRT86)CLIA Kit Customized Service Offer
n/aELISA Kit for Keratin 86 (KRT86)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Keratin 86 (KRT86)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Keratin 86 (KRT86)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Keratin 86 (KRT86)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Keratin 86 (KRT86)CLIA Kit Customized Service Offer
n/aELISA Kit for Keratin 86 (KRT86)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Keratin 86 (KRT86)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Keratin 86 (KRT86)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Keratin 86 (KRT86)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Keratin 86 (KRT86)CLIA Kit Customized Service Offer
n/aELISA Kit for Keratin 86 (KRT86)ELISA Kit Customized Service Offer
  1. "Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle."J. Invest. Dermatol. 110:158-164(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Sequences and differential expression of three novel human type-II hair keratins."Differentiation 61:187-194(1997) [PubMed] [Europe PMC] [Abstract]
  4. "A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix."Hum. Genet. 101:165-169(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Monilethrix: a novel mutation (Glu402Lys) in the helix termination motif and the first causative mutation (Asn114Asp) in the helix initiation motif of the type II hair keratin hHb6."J. Invest. Dermatol. 113:263-266(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: implications for protein structure and clinical phenotype."J. Invest. Dermatol. 113:607-612(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Two different mutations in the same codon of a type II hair keratin (hHb6) in patients with monilethrix."J. Invest. Dermatol. 113:1123-1127(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Novel KRT83 and KRT86 mutations associated with monilethrix."Exp. Dermatol. 24:222-224(2015) [PubMed] [Europe PMC] [Abstract]