V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)

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ERAS; HRASP; ES Cell Expressed Ras; Embryonic stem cell-expressed Ras; GTPase ERas

V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)
Point mutations of several amino acids of HRAS, including gly12, ala59, or glu63, render the protein constitutively active.human ERAS has serine, alanine, and asparagine at the positions corresponding to gly12, ala59, and glu63 of HRAS, suggesting that it is constitutively active. 95% of mouse and human ERAS was in a GTP-bound form. In contrast, about 90% of wildtype HRAS existed in a GTP-bound form, whereas 80% of a constitutively active HRAS mutant was in a GTP-bound form. The predicted 227-amino acid ERas protein shares 43%, 46%, and 47% identity with HRas, KRas, and NRas, respectively, and 5 domains essential for small G proteins are highly conserved. ERas contains a CAAX motif and is located in a cytoplasmic membrane. Northern blot analysis detected a 1.2-kb ERas transcript in several undifferentiated mouse ES cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)CLIA Kit Customized Service Offer
n/aELISA Kit for V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)CLIA Kit Customized Service Offer
n/aELISA Kit for V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 (HRAS2)ELISA Kit Customized Service Offer
  1. "Role of Eras in promoting tumor-like properties in mouse embryonic stem cells."Nature 423:541-545(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]