Homeobox Protein B13 (HOXB13)
HOXB13 encodes a transcription factor that belongs to the homeobox gene family. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.The 60-amino acid homeodomain near the C terminus of HOXB13 shares 78 to 83% identity with HOX proteins in paralog group-13 of the AbdB subfamily; 6 of the amino acid differences from other members of this group represent conservative changes. Moreover, HOXB13 shares less than 60% identity with other AbdB-related genes.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Homeobox Protein B13 (HOXB13)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Homeobox Protein B13 (HOXB13)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Homeobox Protein B13 (HOXB13)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Homeobox Protein B13 (HOXB13)CLIA Kit Customized Service Offer
n/aELISA Kit for Homeobox Protein B13 (HOXB13)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Homeobox Protein B13 (HOXB13)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Homeobox Protein B13 (HOXB13)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Homeobox Protein B13 (HOXB13)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Homeobox Protein B13 (HOXB13)CLIA Kit Customized Service Offer
n/aELISA Kit for Homeobox Protein B13 (HOXB13)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Homeobox Protein B13 (HOXB13)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Homeobox Protein B13 (HOXB13)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Homeobox Protein B13 (HOXB13)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Homeobox Protein B13 (HOXB13)CLIA Kit Customized Service Offer
n/aELISA Kit for Homeobox Protein B13 (HOXB13)ELISA Kit Customized Service Offer
  1. "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity."Development 122:2475-2484(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds."J. Invest. Dermatol. 111:57-63(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Solution structure of the homeobox domain of human homeo box B13."Submitted (NOV-2005) to the PDB data bank
  6. "Complete mutation analysis panel of the 39 human HOX genes."Teratology 65:50-62(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer."Cancer Epidemiol. Biomarkers Prev. 21:1348-1353(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Germline mutations in HOXB13 and prostate-cancer risk." N. Engl. J. Med. 366:141-149(2012) [PubMed] [Europe PMC] [Abstract]
  9. "HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk."Cancer Epidemiol. Biomarkers Prev. 22:452-460(2013) [PubMed] [Europe PMC] [Abstract]
  10. "HOXB13 is a susceptibility gene for prostate cancer: results from the international consortium for prostate cancer genetics (ICPCG)." Hum. Genet. 132:5-14(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort."PLoS Genet. 11:E1004930-E1004930(2015) [PubMed] [Europe PMC] [Abstract]