Fatty Acid Amide Hydrolase (FAAH)

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FAAH-1; Anandamide amidohydrolase 1; Oleamide hydrolase 1

Fatty Acid Amide Hydrolase (FAAH)
Genes from all 3 organisms encode predicted 579-amino acid proteins that each contain a putative transmembrane domain, an amidase consensus sequence, and a putative SH3-binding motif. The sequence of the human protein is 82% and 84% identical to those of rat and mouse FAAH, respectively. Mammalian cells expressing rat or human FAAH exhibited high levels of oleamide hydrolase activity. Western blotting and cell fractionation studies indicated that this activity was associated with a 60 to 65 kD membrane protein. Human and rat FAAHs hydrolyzed a similar variety of fatty acid amides, although the human enzyme was quantitatively somewhat less selective. Northern blot analysis revealed that human FAAH is expressed as a 2.1-kb mRNA in various tissues, but not in heart or lung.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Fatty Acid Amide Hydrolase (FAAH)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Fatty Acid Amide Hydrolase (FAAH)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Fatty Acid Amide Hydrolase (FAAH)Polyclonal Antibody Customized Service Offer
Assay KitsSEQ066HuELISA Kit for Fatty Acid Amide Hydrolase (FAAH)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Fatty Acid Amide Hydrolase (FAAH)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Fatty Acid Amide Hydrolase (FAAH)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Fatty Acid Amide Hydrolase (FAAH)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Fatty Acid Amide Hydrolase (FAAH)CLIA Kit Customized Service Offer
n/aELISA Kit for Fatty Acid Amide Hydrolase (FAAH)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Fatty Acid Amide Hydrolase (FAAH)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Fatty Acid Amide Hydrolase (FAAH)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Fatty Acid Amide Hydrolase (FAAH)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Fatty Acid Amide Hydrolase (FAAH)CLIA Kit Customized Service Offer
n/aELISA Kit for Fatty Acid Amide Hydrolase (FAAH)ELISA Kit Customized Service Offer
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  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use."Hum. Mol. Genet. 13:2113-2119(2004) [PubMed] [Europe PMC] [Abstract]
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  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population."Pharmacogenomics 14:505-514(2013) [PubMed] [Europe PMC] [Abstract]