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Circadian Locomoter Output Cycles Protein Kaput (CLOCK)

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KAT13D; bHLHe8; Class E basic helix-loop-helix protein 8

Circadian Locomoter Output Cycles Protein Kaput (CLOCK)
CCC Q116
HGNC 2082
MGI 99698
PubMed 9630223
RGD 620271
UniProt O15516

Circadian rhythmicity of biologic processes is a fundamental property of all eukaryotic and some prokaryotic organisms. These rhythms are driven by an internal time-keeping system. Changes in the external environment, particularly in the light-dark cycle, entrain this biologic clock.Under constant environmental conditions devoid of time cues, rhythms driven by the biologic clock show a period near, but usually not equal to, 24 hours.

The CLOCK gene encodes a basic helix-loop-helix (bHLH)-PAS transcription factor that is essential for circadian rhythm.The gene encodes an 855-amino acid polypeptide that is a novel member of the bHLH-PAS family of transcription factors and has features predicting DNA binding, protein dimerization, and activation domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ116Hu01 Recombinant Circadian Locomoter Output Cycles Protein Kaput (CLOCK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAQ116Hu01 Polyclonal Antibody to Circadian Locomoter Output Cycles Protein Kaput (CLOCK) WB; IHC; ICC; IP.
MAQ116Hu21 Monoclonal Antibody to Circadian Locomoter Output Cycles Protein Kaput (CLOCK) WB; IHC; ICC; IP.
Assay Kits SEQ116Hu ELISA Kit for Circadian Locomoter Output Cycles Protein Kaput (CLOCK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Circadian Locomoter Output Cycles Protein Kaput (CLOCK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Circadian Locomoter Output Cycles Protein Kaput (CLOCK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Circadian Locomoter Output Cycles Protein Kaput (CLOCK) Polyclonal Antibody Customized Service Offer
Assay Kits SEQ116Mu ELISA Kit for Circadian Locomoter Output Cycles Protein Kaput (CLOCK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Circadian Locomoter Output Cycles Protein Kaput (CLOCK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Circadian Locomoter Output Cycles Protein Kaput (CLOCK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Circadian Locomoter Output Cycles Protein Kaput (CLOCK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Circadian Locomoter Output Cycles Protein Kaput (CLOCK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Circadian Locomoter Output Cycles Protein Kaput (CLOCK) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei."Genomics 57:189-200(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors."Science 293:510-514(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."J. Biol. Chem. 279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Feedback repression is required for mammalian circadian clock function."Nat. Genet. 38:312-319(2006) [PubMed] [Europe PMC] [Abstract]
  8. "CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter."Mol. Cell. Biochem. 317:169-177(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression."J. Biol. Chem. 285:38987-39000(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Biochemical analysis of the canonical model for the mammalian circadian clock."J. Biol. Chem. 286:25891-25902(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man."PLoS ONE 6:E25612-E25612(2011) [PubMed] [Europe PMC] [Abstract]
  12. "A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling."Science 332:1313-1317(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock."Science 333:1881-1885(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Diurnal expression of the thrombopoietin gene is regulated by CLOCK."J. Thromb. Haemost. 10:662-669(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Mechanism of the circadian clock in physiology."Am. J. Physiol. 304:R1053-R1064(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation."J. Biol. Chem. 288:36878-36889(2013) [PubMed] [Europe PMC] [Abstract]
  17. "p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."J. Neurosci. 33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]
  18. "CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha."Oncogene 32:4883-4891(2013) [PubMed] [Europe PMC] [Abstract]
  19. "Metabolism and the circadian clock converge."Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
  20. "A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock."J. Invest. Dermatol. 134:610-619(2014) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Molecular architecture of the mammalian circadian clock."Trends Cell Biol. 24:90-99(2014) [PubMed] [Europe PMC] [Abstract]