EGF Like Repeats And Discoidin I Like Domains Protein 3 (EDIL3)

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DEL1; Integrin-binding protein DEL1; Developmentally-regulated endothelial cell locus 1 protein

EGF Like Repeats And Discoidin I Like Domains Protein 3 (EDIL3)
EDIL3 is a glycoprotein that is secreted by endothelial cells and can associate with the endothelial cell surface and the extracellular matrix. EDIL3 is regulated by hypoxia or vascular injury and has been implicated in vascular remodeling during angiogenesis.The predicted 480-amino acid mouse and human proteins, which are 95% identical, contain a signal peptide, 3 epidermal growth factor (EGF)-like repeats, and 2 discoidin I-like repeats. Northern blot analysis revealed expression of a 6.5-kb transcript in highly vascularized mouse embryonic day-15.5 tissue and in mouse and human endothelial cells, but not in other adult tissues. In situ hybridization analysis showed Del1 expression in developing endocardium at 9.5 days postcoitus and in renal artery and hypertrophic chondrocytes at 13.5 days postcoitus.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPQ266Hu01Recombinant EGF Like Repeats And Discoidin I Like Domains Protein 3 (EDIL3)SDS-PAGE; WB; ELISA; IP.
AntibodiesMAQ266Hu21Monoclonal Antibody to EGF Like Repeats And Discoidin I Like Domains Protein 3 (EDIL3)WB, ICC, IHC-P, IHC-F, ELISA
PAQ266Hu01Polyclonal Antibody to EGF Like Repeats And Discoidin I Like Domains Protein 3 (EDIL3)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEQ266HuELISA Kit for EGF Like Repeats And Discoidin I Like Domains Protein 3 (EDIL3)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant EGF Like Repeats And Discoidin I Like Domains Protein 3 (EDIL3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to EGF Like Repeats And Discoidin I Like Domains Protein 3 (EDIL3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to EGF Like Repeats And Discoidin I Like Domains Protein 3 (EDIL3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for EGF Like Repeats And Discoidin I Like Domains Protein 3 (EDIL3)CLIA Kit Customized Service Offer
n/aELISA Kit for EGF Like Repeats And Discoidin I Like Domains Protein 3 (EDIL3)ELISA Kit Customized Service Offer
  1. "Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor."Genes Dev. 12:21-33(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The RGD finger of Del-1 is a unique structural feature critical for integrin binding."FASEB J. 26:3412-3420(2012) [PubMed] [Europe PMC] [Abstract]