POU Domain Class 6 Transcription Factor 1 (POU6F1)

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BRN5; MPOU; TCFB1; Brain-5; Brain-specific homeobox/POU domain protein 5; mPOU homeobox protein

POU Domain Class 6 Transcription Factor 1 (POU6F1)
Expression of POU6F1 at messenger RNA and protein was confirmed in cell lines derived from epithelial ovarian carcinoma. The microarray analyses performed using the 2 ovarian cancer microarray data sets available on the Internet indicated that POU6F1 expression was significantly greater in clear cell adenocarcinoma. Immunostaining confirmed the nuclear localization of POU6F1 in clear cell adenocarcinoma (100%).
Exposure to the siRNA for POU6F1 reduced the expression of lysophosphatidic acid receptors, which are G protein-coupled receptors involved in tumor cell proliferation. POU6F1 siRNA dose-dependently suppressed the proliferation of clear cell adenocarcinoma cell lines, and a similar effect was confirmed for tumors transplanted into nude mice.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant POU Domain Class 6 Transcription Factor 1 (POU6F1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)CLIA Kit Customized Service Offer
n/aELISA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant POU Domain Class 6 Transcription Factor 1 (POU6F1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)CLIA Kit Customized Service Offer
n/aELISA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant POU Domain Class 6 Transcription Factor 1 (POU6F1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to POU Domain Class 6 Transcription Factor 1 (POU6F1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)CLIA Kit Customized Service Offer
n/aELISA Kit for POU Domain Class 6 Transcription Factor 1 (POU6F1)ELISA Kit Customized Service Offer
  1. "A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
  2. "A novel POU domain protein which binds to the T-cell receptor beta enhancer."Mol. Cell. Biol. 13:5450-5460(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]