GS Homeobox Protein 2 (GSX2)
The ETV6 gene is a frequent target of chromosomal translocations in both myeloid and lymphoid leukemias. At present, more than 40 distinct translocations have been cytogenetically described, of which 13 have now also been characterized at the molecular level. The homeobox gene GSH2 at 4q11-q12 and the IL-3/CSF2 locus at 5q31 were found to be located close to the respective breakpoints. In addition, GSH2 and IL-3 were found to be ectopically expressed in the leukemic cells, suggesting that expression of GSH2 and IL-3 was deregulated by the translocation. Besides the generation of fusion transcripts, deregulation of the expression of oncogenes could be a variant leukemogenic mechanism for translocations involving the 5' end of ETV6, especially for those translocations lacking functionally significant fusion transcripts.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant GS Homeobox Protein 2 (GSX2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to GS Homeobox Protein 2 (GSX2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to GS Homeobox Protein 2 (GSX2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for GS Homeobox Protein 2 (GSX2)CLIA Kit Customized Service Offer
n/aELISA Kit for GS Homeobox Protein 2 (GSX2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant GS Homeobox Protein 2 (GSX2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to GS Homeobox Protein 2 (GSX2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to GS Homeobox Protein 2 (GSX2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for GS Homeobox Protein 2 (GSX2)CLIA Kit Customized Service Offer
n/aELISA Kit for GS Homeobox Protein 2 (GSX2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant GS Homeobox Protein 2 (GSX2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to GS Homeobox Protein 2 (GSX2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to GS Homeobox Protein 2 (GSX2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for GS Homeobox Protein 2 (GSX2)CLIA Kit Customized Service Offer
n/aELISA Kit for GS Homeobox Protein 2 (GSX2)ELISA Kit Customized Service Offer
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]