NADH Dehydrogenase 2 (ND2)

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MT-ND2; MTND2; NAD2; NADH-Ubiquinone Oxidoreductase Chain 2; Mitochondrially Encoded NADH Dehydrogenase 2

NADH Dehydrogenase 2 (ND2)
MTND2 belongs to the complex I subunit 2 family. Defects in MT-ND2 are a cause of Leber hereditary optic neuropathy (LHON) . LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ND2 may be associated with susceptibility to Alzheimer disease mitochondrial (AD-MT) . Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant NADH Dehydrogenase 2 (ND2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to NADH Dehydrogenase 2 (ND2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to NADH Dehydrogenase 2 (ND2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for NADH Dehydrogenase 2 (ND2)CLIA Kit Customized Service Offer
n/aELISA Kit for NADH Dehydrogenase 2 (ND2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant NADH Dehydrogenase 2 (ND2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to NADH Dehydrogenase 2 (ND2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to NADH Dehydrogenase 2 (ND2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for NADH Dehydrogenase 2 (ND2)CLIA Kit Customized Service Offer
n/aELISA Kit for NADH Dehydrogenase 2 (ND2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant NADH Dehydrogenase 2 (ND2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to NADH Dehydrogenase 2 (ND2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to NADH Dehydrogenase 2 (ND2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for NADH Dehydrogenase 2 (ND2)CLIA Kit Customized Service Offer
n/aELISA Kit for NADH Dehydrogenase 2 (ND2)ELISA Kit Customized Service Offer
  1. "Sequence and organization of the human mitochondrial genome."Nature 290:457-465(1981) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing."J. Mol. Biol. 143:161-178(1980) [PubMed] [Europe PMC] [Abstract]
  3. "Departure from neutrality at the mitochondrial NADH dehydrogenase subunit 2 gene in humans, but not in chimpanzees."Genetics 148:409-421(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs."Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J."Mol. Biol. Evol. 20:2132-2142(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Mitochondrial genome variation and the origin of modern humans."Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines."Genome Res. 13:1600-1606(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians."Int. J. Legal Med. 118:137-146(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase."Nature 314:592-597(1985) [PubMed] [Europe PMC] [Abstract]
  10. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Alternative, simultaneous complex I mitochondrial DNA mutations in Leber's hereditary optic neuropathy."Biochem. Biophys. Res. Commun. 174:1324-1330(1991) [PubMed] [Europe PMC] [Abstract]
  13. "Normal variants of human mitochondrial DNA and translation products: the building of a reference data base."Hum. Genet. 88:139-145(1991) [PubMed] [Europe PMC] [Abstract]
  14. "Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy."Genetics 130:163-173(1992) [PubMed] [Europe PMC] [Abstract]
  15. "Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains."Biochem. Biophys. Res. Commun. 182:238-246(1992) [PubMed] [Europe PMC] [Abstract]
  16. "Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome."Nucleic Acids Res. 26:967-973(1998) [PubMed] [Europe PMC] [Abstract]