POU Domain Class 5 Transcription Factor 1B (POU5F1B)

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OTF3C; OTF3P1; POU5F1; OCT4PG1; POU5F1P1; POU5FLC20; POU5FLC8; Octamer-binding protein 3-like; Octamer-binding transcription factor 3-like

POU Domain Class 5 Transcription Factor 1B (POU5F1B)
POU5F1B is a transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). It may exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell. The isolation of cDNAs encoding Oct3 revealed the expression of two isoforms of this transcription factor termed Oct3A and Oct3B that are generated by alternative splicing. Human Oct3A and Oct3B are composed of 360 and 265 amino acids, respectively, of which the 225 amino acids at the COOH-termini are identical.The human Oct3 gene, localized to human chromosome 6 in the region of the MHC complex, spans about 7 kb and consists of five exons. The Oct3-related gene, OTF3C, is a retroposon and has been localized to human chromosome 8. Southern blotting and PCR amplification of human DNA indicated the presence of other OTF3-related genes as has been previously noted in the mouse.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant POU Domain Class 5 Transcription Factor 1B (POU5F1B)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to POU Domain Class 5 Transcription Factor 1B (POU5F1B)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to POU Domain Class 5 Transcription Factor 1B (POU5F1B)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for POU Domain Class 5 Transcription Factor 1B (POU5F1B)CLIA Kit Customized Service Offer
n/aELISA Kit for POU Domain Class 5 Transcription Factor 1B (POU5F1B)ELISA Kit Customized Service Offer
  1. "Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues."Nucleic Acids Res. 20:4613-4620(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Emergence of young human genes after a burst of retroposition in primates."PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma."J. Pathol. 223:672-682(2011) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Oct4 pseudogenes are transcribed in cancers."Biochem. Biophys. Res. Commun. 337:1047-1051(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1."Oncol. Rep. 20:1029-1033(2008) [PubMed] [Europe PMC] [Abstract]