Methionyl Aminopeptidase 1D (METAP1D)

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Metap1l; MAP1D; Methionine aminopeptidase 1D, mitochondrial; Peptidase M 1D

Methionyl Aminopeptidase 1D (METAP1D)
MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer.The enzymes that catalyze this reaction are called Methionine Aminopeptidases (MAPs). To date, only two MAP family members, MAP1A and MAP2, have been well characterized and studied in mammals. MAP1D Expression and purification of full length recombinant protein shows that the sequence encodes an enzyme with MAP activity. MAP1D is overexpressed in colon cancer cell lines and in colon tumors as compared to matched normal tissue samples. Downregulation of MAP1D expression by shRNA in HCT-116 colon carcinoma cells reduces anchorage-independant growth in soft agar. These data suggest that MAP1D is a potentially oncogenic, novel member of the MAP gene family that may play an important role in colon tumorigenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methionyl Aminopeptidase 1D (METAP1D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methionyl Aminopeptidase 1D (METAP1D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionyl Aminopeptidase 1D (METAP1D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionyl Aminopeptidase 1D (METAP1D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionyl Aminopeptidase 1D (METAP1D) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methionyl Aminopeptidase 1D (METAP1D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methionyl Aminopeptidase 1D (METAP1D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionyl Aminopeptidase 1D (METAP1D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionyl Aminopeptidase 1D (METAP1D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionyl Aminopeptidase 1D (METAP1D) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methionyl Aminopeptidase 1D (METAP1D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methionyl Aminopeptidase 1D (METAP1D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionyl Aminopeptidase 1D (METAP1D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionyl Aminopeptidase 1D (METAP1D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionyl Aminopeptidase 1D (METAP1D) ELISA Kit Customized Service Offer
  1. "An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway."J. Biol. Chem. 278:52953-52963(2003) [PubMed] [Europe PMC] [Abstract]
  2. "MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer."Oncogene 25:3471-3478(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases."Biochemistry 46:12833-12843(2007) [PubMed] [Europe PMC] [Abstract]