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Neuraminidase 1 promotes renal fibrosis development in male mice
On March 27, 2023,Lian-Wen Qi and Lei Zhang, State Key Laboratory of Natural Medicines, China Pharmaceutical University, China, and their team published a paper titled “Neuraminidase 1 promotes renal fibrosis development in male mice” in Nature Communications. This study characterizes a promotor role for NEU1 in renal fibrosis and suggests a potential avenue of targeting NEU1 to treat kidney diseases.The antibody[FITC-Linked Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1),LAA785Mu81] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.The functions of the influenza virus neuraminidase has been well documented but those of the mamma......
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New Progress in the research of Anxiety Disorders
Anxiety disorders are among the most prevalent and disabling psychiatric disorders. The core feature of anxiety disorders is excessive fear and anxiety and related behavioral disturbances.Patients with anxiety disorders experience substantial physical and emotional discomfort and have elevated rates of substance use and medical illnesses.Furthermore, anxiety disorders are characterized by high comorbidity along with other mental disorders (eg, mood, substance-abuse, or personality disorders). Compounding this, response rates to first-line pharmacological and psychological treatments are less than 50%. Recently, several papers have reported anxiety related studies, which may provide hel......
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OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2
On April 7, 2023, Lingqiang Zhang's team, State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, China, and Cui Hua Liu's team, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, China, published a paper titled “OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2” in Signal Transduction and Targeted Therapy. Their results suggested that OTUB1 positively regulates osteogenic differentiation and mineralization in bone homeostasis by controlling FGFR2 stability.The kits [ELISA Kit for Cross Linked C-Telopeptide Of Type I Collagen (CTX......
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自然杀伤细胞篇——第一回 自然杀伤细胞受体及其配体
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New progress in antibody therapy of cancer
Cancer therapy using monoclonal antibodies (mAbs) is a rapidly developing field, due in large part to naturally favorable attributes such as specificity, potency, and metabolic stability. Most of them act by binding to transmembrane receptors or soluble ligands, thereby interfering with their signal transduction pathways, resulting in inhibition of tumor cell proliferation or angiogenesis. Due to the presence of an intact Fc domain, mAbs can evoke antibody-dependent cell-mediated cytotoxicity by attracting complement or effector cells of the human immune system to the cancer site. mAbs have also been used as targeting moieties for the delivery of nanomedicinesor conjugating to cytotoxi......
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Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K-AKT-PDGF axis activation in male mice
On March 14, 2023,Ni Tang, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, China, and his team published a paper titled “Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice” in Nature Communications. They showed that hepatic PCK1 deficiency may be important in hepatic steatosis and fibrosis development through paracrine secretion of PDGF-AA in male mice.The kits [ELISA Kit for Platelet Derived Growth Factor AA (PDGFAA), SEA523Mu, SEA523Hu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Metabolic as......