Interleukin 10 (IL10)

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CSIF; IL10A; TGIF; Cytokine Synthesis Inhibitory Factor

Interleukin 10 (IL10)

Interleukin-10 is a small protein known as a cytokine that functions as an important regulator of the immune system.  Although IL-10 is known to have many different roles in the immune system, its two major activities include inhibition of cytokine production by macrophages and inhibition of the accessory functions of macrophages during T cell activation. The effects of these actions cause IL-10 to play mainly an anti-inflammatory role in the immune system. 

IL-10 was originally known as the cytokine synthesis inhibiting factor (CSIF), and the discovery of this protein was based on its biological activity. IL-10 is mainly produced by the Th2 subset of CD4+ helper cells.  However, it is also produced by some activated B cells, some Th1 cells , activated macrophages, and some nonhematopoietic sources .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Hu01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
RPA056Hu02 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
EPA056Hu61 Eukaryotic Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
APA056Hu61 Active Interleukin 10 (IL10) Cell culture; Activity Assays.
APA056Hu01 Active Interleukin 10 (IL10) Cell culture; Activity Assays.
Antibodies PAA056Hu01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Hu22 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
LAA056Hu71 Biotin-Linked Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC.
PAA056Hu02 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
PAA056Hu06 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Hu21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
Assay Kits SEA056Hu ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA056Hu CLIA Kit for Interleukin 10 (IL10) Chemiluminescent immunoassay for Antigen Detection.
HEA056Hu High Sensitive ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Mu01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
RPA056Mu02 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
EPA056Mu61 Eukaryotic Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
APA056Mu61 Active Interleukin 10 (IL10) Cell culture; Activity Assays.
Antibodies PAA056Mu01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
LAA056Mu71 Biotin-Linked Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC.
LAA056Mu81 FITC-Linked Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IF.
PAA056Mu02 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Mu21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
Assay Kits SEA056Mu ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA056Mu CLIA Kit for Interleukin 10 (IL10) Chemiluminescent immunoassay for Antigen Detection.
HEA056Mu High Sensitive ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Ra01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
EPA056Ra61 Eukaryotic Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
APA056Ra61 Active Interleukin 10 (IL10) Cell culture; Activity Assays.
APA056Ra01 Active Interleukin 10 (IL10) Cell culture; Activity Assays.
Antibodies PAA056Ra01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Ra21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
PAA056Ra06 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
LAA056Ra71 Biotin-Linked Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC.
Assay Kits SEA056Ra ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.
HEA056Ra High Sensitive ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Gu01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA056Gu01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Gu21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
Assay Kits SEA056Gu ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Rb01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
EPA056Rb61 Eukaryotic Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA056Rb51 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Rb21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
Assay Kits SEA056Rb ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Si01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA056Si01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Si21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
Assay Kits SEA056Si ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Ca01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
EPA056Ca61 Eukaryotic Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
APA056Ca61 Active Interleukin 10 (IL10) Cell culture; Activity Assays.
Antibodies PAA056Ca01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Ca21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
PAA056Ca06 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
Assay Kits SEA056Ca ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Po01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA056Po01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Po21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
Assay Kits SEA056Po ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Bo01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
EPA056Bo61 Eukaryotic Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA056Bo01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Bo21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
Assay Kits SEA056Bo ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.
HEA056Bo High Sensitive ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Cp01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA056Cp01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Cp21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
Assay Kits SEA056Cp ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Eq01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA056Eq01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Eq21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
Assay Kits SEA056Eq ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Ga01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
EPA056Ga61 Eukaryotic Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA056Ga01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Ga21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
Assay Kits SEA056Ga ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA056Fi01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interleukin 10 (IL10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 10 (IL10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 10 (IL10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 10 (IL10) ELISA Kit Customized Service Offer
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  9. "Crystal structure of human interleukin-10 at 1.6-A resolution and a model of a complex with its soluble receptor."Protein Sci. 5:1955-1962(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site."Immunity 15:35-46(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain."Structure 13:551-564(2005) [PubMed] [Europe PMC] [Abstract]
  12. "A Gly15Arg mutation in the interleukin-10 gene reduces secretion of interleukin-10 in Crohn disease."Scand. J. Gastroenterol. 38:611-617(2003) [PubMed] [Europe PMC] [Abstract]