Cloud-Clone Clinical Diagnostic Reagents and Raw Materials #Arginase Antibody Reagent
Arginase (ARG) is an enzyme involved in the urea cycle, which catalyzes the hydrolysis of L-arginine into L-ornithine and urea.The content of ARG in liver isthe highest, followed by kidney, heart, spleen and skeletal muscle.ARG plays an important role in protecting cells from NH3 poisoning and cell growth and repair. In addition, studies have shown that the excessive activity of the ARG/ornithine pathway promotes cardiovascular and renal dysfunction and damage, and plays a role in the progression of central nervous system diseases and cancer. Therefore, ARG detection can help in the diagnosis and treatment of cardiovascular, renal and central nervous system diseases, as well as cancer.
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy
Journal：nature communicationsIF：14.919On November11, 2021, Matthias Kettwig, Gogentine University Medical Center, Germany,and his team , published a paper titled "Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy" on Nature Communications, which suggested that RNaseT2-/-mice can be used to study central nervous system damage associated with RnaseT2 defects.The antibody (Polyclonal Antibody to Ribonuclease T2 (RNASET2), PAA113Mu01) of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Infantile-onset RNaseT2 deficient leukoencephalopathy is characterised by cystic brainlesions, multifocal w......
New progress in the study of inflammatory arthritis disease mechanism
Inflammatory arthritis, including spinal arthritis (SpA) and rheumatoid arthritis (RA), are a kind of chronic inflammatory diseases, which will gradually damage the joints of patients and have a negative impact on normal life.SpA is characterized by inflammation in distinct anatomical sites and abnormal new bone formation in the entheses of the spine and peripheral joints; RA is characterized by the production of autoantibodies against extracellular matrix proteins and other targets, synovial inflammation and hyperplasia, and progressive cartilage and bone erosion.New progress in inflammatory arthritis researchThe use of anti-inflammatory drugs, including biologics, may relieve inflamm......
Cloud-Clone Clinical Diagnostic Reagents and Raw Materials #CTSD Antibody Reagent
Cathepsin D is an important proteolytic enzyme, mainly distributed in intracellular vesicles, lysosomes, phagosomes and secondary endosomes. Its normal function is to participate in the catabolism of connective tissue. Current studies have shown that Cathepsin D is highly expressed in endometrial cancer, ovarian cancer, gastric cancer, breast cancer and other tumors, and plays an important role in the mechanism of malignant tumor cell infiltration and metastasis. Therefore, Cathepsin D detection is of great significance for the diagnosis and treatment evaluation of malignant tumor diseases.
A pair of dopamine neurons mediate chronic stress signals to induce learning deficit in Drosophila melanogaster
On October 19, 2021, Hongtao Qin, School of Biology, Hunan University, and his team , published a paper titled "A pair of dopamine neurons mediate chronic stress signals to induce learning deficit in Drosophila melanogaster" on PNAS, which suggested that chronic stress causes dramatic learning and memory deficits in drosophila melanogaster.The ELISA Kits (ELISA Kit for Dopamine (DA), CEA851Ge) of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Chronic stress could induce severe cognitive impairments. Despite extensive investigations in mammalian models, the underlying mechanisms remain obscure. Here, we show that chronic stress cou......
New strategies for triple-negative breast cancer treatment
Breast cancer (BC) is the most common malignancy in women. Due to advances in early diagnosis and comprehensive treatment strategies, the prognosis of breast cancer patients has improved. The disease has been divided into different subtypes, largely on the basis of the presence or absence of three key proteins: estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/ERBB2). Among them, triple negative breast cancer (TNBC) with negative expression of ER, PR and HER2/ERBB2 is the most difficult type of breast cancer treatment at present.New treatment strategies for TNBCTNBC has been characterized by several aggressive clinical features inclu......