Diabetic cardiomyopathy (DCM) is a specific form of heart disease caused by the progression of resistance to insulin metabolism in the heart tissue, compensatory hyperinsulinemia, and hyperglycemia, which occurs independently of other cardiac risk factors, such as coronary artery disease and high blood pressure. This form of cardiomyopathy is a major cause of morbidity and mortality in developed countries, and its prevalence is rising with the increasing incidence of obesity and type 2 diabetes. DCM observed in insulin resistance or hyperinsulinemia states is characterized by impaired myocardial insulin signaling, mitochondrial dysfunction, endoplasmic reticulum stress, impaired calciu......2024-07-23

Despite recent therapeutic advancements, ovarian cancer continues to exhibit the highest mortality rate among gynecological malignancies. In most cases, ovarian cancer is managed through repeated cycles of platinum-based chemotherapy. Although tumors initially respond to this treatment, they inevitably develop drug resistance, leading to relapse. The acquisition of drug resistance during therapy has long been viewed as a process entirely confined to the molecular events occurring within cancer cells.However, recent data suggest an interesting scenario where the cancer cell death induced by initial therapy promotes subsequent expansion of the survived clones.During chemotherapy, dying t......2024-07-22

Under normal circumstances, moderate pyroptosis helps to clear infected cells in time, but excessive activation of pyroptosis can lead to massive cell death, serious tissue damage and organ failure, which is related to the pathogenesis of some diseases. Nowadays, due to the increasing incidence of liver disease, it has become a serious health problem in the world. Some of them progress to cirrhosis and hepatocellular carcinoma (HCC), which is a serious threat to human life. Studies have shown that pyroptosis is one of the causes of liver disease development. Due to the presence of gut-liver axis in the body, when the gut microbiota is imbalanced, the gut microbiota can enter the liver.......2024-07-22

Sleep is a natural and reversible state, mainly controlled by neurobiological processes, and is an essential physiological part of human life to maintain health. Sleep has a multifaceted impact on the body, reducing energy expenditure, increasing the recovery of energy stores in the brain, regulating adaptive and innate immune responses, and helping to consolidate memories. Sleep quality is affected by many factors, such as diet, physical activity, genetic and environmental factors. Sleep disorder is a very common disease, which disturbs the normal circadian rhythm and has a negative impact on mental and physical health.Sleep disorders are associated with the occurrence and development......2024-04-09

Anxiety is one of the most prevalent psychiatric disorders. Cumulative evidence suggests that increased inflammation is an important pathway for stress-induced anxiety disorders. Microglia, the principal immune cells in the brain, play a central role in neuroinflammation, immune surveillance, and maintenance of brain homeostasis. Anti-inflammatory cytokines intervention or anti-inflammatory drug treatment improves anxiety-like behavior in rodents. Thus, anti-inflammatory therapy targeting microglia may be one of the effective treatment strategies for anxiety disorder clinically.Na+/K+-ATPase (NKA) is a well-known transmembrane protein composed of α, β, and γ subunits, and plays an i......2024-04-09

Kidney stones are mineral deposits in the renal calyces and pelvis that are found free or attached to the renal papillae. Stone formation is highly prevalent, with a high incidence worldwide and increasing year by year.And a recurrence rate of up to 50% within the first 5 years of the initial stone episode. Obesity, diabetes, hypertension and metabolic syndrome are considered risk factors for stone formation, which, in turn, can lead to hypertension, chronic kidney disease and end-stage renal disease.Management of symptomatic kidney stones has evolved from open surgical lithotomy to minimally invasive endourological treatments leading to a reduction in patient morbidity, improved stone......2024-03-11