On 16 June 2022, Xiangming Mao, Department of Urology, Zhujiang Hospital, Southern Medical University, China, and his team published a paper titled “Gut dysbiosis promotes prostate cancer progression anddocetaxel resistance viaactivating NF-κB-IL6-STAT3 axis” in Microbiome, which demonstrated that gut dysbiosis resulted in the elevation of gut permeability and intratumoral LPS, promoting the development of prostate cancer via the NF-κB-IL6-STAT3 axis in mice.The antibodies [Monoclonal Antibody to Lipopolysaccharide (LPS), MAB526Ge22]and kits [ELISA Kit for Lipopolysaccharide (LPS), SEB526Ge]of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaser......2022-07-20

A Brief Introduction of MonkeypoxRecently, monkeypoxvirus is widespread in west and central Africa, which attracts global attention. The World Health Organization (WHO) statesthat monkeypox constitutes a "moderate risk" to overall public health at the global level after cases were reported in countries, but it is not ruled out that the risk level may be increased with the spread of the virus in future days. Notably, this is the first time monkeypox virus has spread in multiple "non-endemic countries" outside of Central and West Africa, with human-to-human transmission.Like smallpox virus and vaccinia virus, monkeypox virus belongs to the Orthopoxvirus genus, and the......2022-07-18

On 6 June 2022, Jie Na, Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, China, and his team published a paper titled “Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction” in Nature Communications.In this study, they found that JUNB is an essential regulator for hemogenic endothelium specialization and endothelial-to-hematopoietic transition.The antibodies [None-Linked Guinea pig Anti-Rabbit IgG Polyclonal Antibody, SAA544Rb50] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Human pluripotent stem cell differentiation toward......2022-07-14

Colorectal cancer (CRC) is one of the most common human malignancies accounting for approximately 10% of worldwide cancer incidence and mortality. While early-stage CRC is curable by surgery, treatment of metastatic colorectal cancer (mCRC) remains an unmet clinical need. Moreover, about 25% of CRC cases are diagnosed only at the metastatic stage. Despite the extensive molecular and functional knowledge on this disease, systemic therapy for mCRC still relies on traditional 5-fuorouracil (5-FU)-based chemotherapy regimens. So far, targeted therapies and immunotherapy have shown effectiveness only in a limited subset of CRC patients. Therefore, there is an urgent need to understand the m......2022-07-08

On 23 May 2022, Yiguang Wang, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, China, and Fuping You, Institute of Systems Biomedicine, Department of Immunology, Beijing Key Laboratory of Tumour Systems Biology, Peking University Health Science Center, China, and their team published a paper titled “A pyroptosis nanotuner for cancer therapy” in Nature Nanotechnology, which offers new insights into how to engineer nanomedicines with tunable pyroptosis activity through specific targeting of distinct endocytic signalling for biomedical applications.The kits [ELISA Kit for Inositol Triphosphate (IP3), CEC037Ge] of Cloud-Clone b......2022-07-06

On May 23,2022, professor Yiguang Wang from State Key Laboratory of Natural and Biomimetic Drugs, School of PharmaceuticalSciences,Peking University published a paper titled A pyroptosis nanotumer for cancer therapy on Nature Namotechmology.Pyroptosis is a gasdermin-mediated programmed necrosis that occurs via membrane perforation and that can be exploited for biomed-ical applications in cancer therapy. However, inducing specific pyroptotic cancer cell death while sparing normal cells is challenging.Here, we report an acid-activatable nanophotosensitizer library that can be used to spatiotemporally target distinctstages of endosomalmaturation, cnabling tumnable cellular pyroptosis. Spe......2022-06-27