The “Ark project” Cloud-Clone devotes to assisting scientific research during COVID-19!
In early 2020, a sudden COVID-19 epidemic interrupted the research projects of universities and research institutes around the world, and even responded to the current situation by delaying the opening of schools and temporarily closing the laboratory.But the academic demands and the publication of papers still had to be worked out under such a pressing situation.Therefore, Cloud-clone Animal Co.,Ltd (CCA) will undertake individual or overall experimental services to assist global users, which is called the “Ark project”. We will do our best to follow the user's experimental design, to ensure the timely completion of the experimental project, for your scientific research escort......
Literature of Cloud Clone products in Apr. 2020 (Excerpt)
In Apr. 2020, Literature of Cloud Clone products has exceeded 210. Cloud-Clone could provide multipleproteins, antibodies and ELISA kit, which has been praised by customers.（For more information, please visit: www.cloud-clone.com/www.uscnk.cn）
Potential Target for Drug of SARS-CoV-2
The outbreak of Corvid 19 leads to more than two millions patients in the world. Researchers from various countries had done extensive work in studying the mechanism of virus infection, screening of effective drugs and searching for potential targets for new drugs. Previously studies showed that the invasion of the virus depends onACES,CD147and TMPRSS2.In March, A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug Repurposing was jointly researched and published on Biorxiv by researchers from the United States, Britain and France.By analyzing the genome of SARS-CoV-2, 28 viral proteins were cloned and expressed, including 4 structural proteins (S, ......
The second key protein of SARS-CoV-2 infection, CD147
SARS-COV-2 spreads all over the worldandseriously threatens human health. Previously, we introduced ACE2, the first key protein of covid-19 infection. Now, we will introduce another key protein, CD147.CD147, also known as Basigin or EMMPRIN, is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. CD147 is highly expressed in various tumor cells and tissues, and promotes tumor invasion and metastasis by inducing the secretion of matrix metalloproteinases. Studies show that CD147 is also related to plasmodium invasion and virus infection.How does CD147 help SARS-COV-2 infect host cells?1.Structure of coronavirusCoronavirus has four structural proteins, including:E......
Why can the poison king bats be invulnerable to attack from a high burden of deadly viruses
Recently, bats are the hottest internet celebrities in the animal world. Here we should say sorry to pangolin. The SARS-CoV-2 is causing an outbreak of viral pneumonia after SARS-CoV. This outbreak began in the city of Wuhan, Hubei Province, China in the early December 2019. Then it continues to spread throughout China. According to many researches, bats are the original source of SARS-CoV-2. As a movable virus reservoir, bats are invulnerable to attack from a variety of formidable viruses, such as EBoV, MV, RV, SARS-CoV, MERS-CoV, SARS-CoV-2 and so on. People are often curious about bats antiviral ability.Why are the bats invulnerable to attack from viruses?What makes bats so special?......
An accomplice of the coronavirus-ACE2
WhyACE2(Angiotensin I Converting Enzyme 2)is called"accomplice" to coronavirus?Let's start with the coronavirus.The characteristic appearance of virions lookslike solar corona or crown by electron microscopy, hence the namecoronavirus.The viruses can bedivided into four genera(α, β, γand δ), SARS-CoV, MERS-CoV and SARS-CoV-2 (previously known as 2019-nCoV), belong to the βgenus.Figure 1shows the illustration of the morphology of SARS-CoV-2.Figure1.Illustration of the morphology of SARS-CoV-2(This image is from Wikipedia)The coronavirus is the largest known RNA virus with the largest genome.Proteins that contribute to the overall structure of coronaviruses are the spi......