On August 12, 2020, professor Barbara Pui Chan from The University of Hong Kong published a paper on Biomaterials. The paper titled Mechanically induced formation and maturation of 3D-matrix adhesions (3DMAs) in human mesenchymal stem cells.The ELISA kit (ITGaV, SEB282Hu) of Cloud-Clone brand was chosed to determine the concentation of ITGaV in this article, we are so proud for supporting the reaserchersMechanical signal is important for regulating stem cell fate, but the molecular mechanisms involved are unclear. Cell-matrix adhesions are important molecular mechanosensors that their formation and maturation are force-dependent processes. However, most studies focused on the role of......2020-09-25

On August 17, 2020, professor Lino Ferreira from University of Coimbra published a paper titled Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13 on Nature communications.The ELISA kit (MMP13, SEA099Mu) of Cloud-Clone brand was chosed to determine the concentation of MMP13 in this article, we are so proud for supporting the reaserchers.Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, although the reason for such vulnerability remains poorly understood. In this work, we develop a microfluidic chip formed by ......2020-09-25

On July 19, 2020, professor Wei Chi from Zhongshan Ophthalmic Center of Sun Yat-sen University published a paper on The Ocular Surface. The paper titled NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye.The recombinant protein kit (GSDMD, RPE529Mu01) of Cloud-Clone brand was chosed to rescue GSDMD KO mice in this article, we are so proud for supporting the reaserchers.Dry eye disease (DED) is a common and multifactor-induced autoimmune ocular surface disease. Environmental factors, such as desiccating stress (DS) and hyperosmolarity, affect the corneal epithelium to induce ocular surface inflammation in DED......2020-09-25

In July, 2020, professor Kai-Fu Tang from the First Affiliated Hospital of Wenzhou Medical University published a paper on Theranostics. The paper titled Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis.The ELISA kit (8OHdG, CEA660Ge) of Cloud-Clone brand was chosed to determine the concentation of 8OHdG in this article, we are so proud for supporting the reaserchers.Chronic inflammation is known to promote carcinogenesis; Dicer heterozygous mice are more likely to develop colitis-associated tumors. This study investigates whether Dicer is downregulated in inflamed colon tissues before malignancy occurs and whether ......2020-09-24

On July 15, 2020, professor Samuel C Mok from The University of Texas MD Anderson Cancer Center coauthored with professor Deepak Nagrath from University of Michigan published a paper on Nature communications. The paper titled ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment.The ELISA kit ((ITLN1, SEA933Mu) of Cloud-Clone brand was chosed to determine the concentation of ITLN1 in this article, we are so proud for supporting Advanced ovarian cancer usually spreads to the omentum. However, the omental cell-derived molecular determinants modulating its progression have not been thoroughly characterized. Here, we show that ......2020-09-24

On July 7, 2020, professor Kenta Maruyama from Osaka University WPI Immunology Frontier Research Center published a paper on Cell. The paper titled RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis.The ELISA kit (CTX1, CEA665Mu) of Cloud-Clone brand was chosed to determine the concentation of PVR in this article, we are so proud for supporting the reaserchers.Gastrointestinal enterochromaffin cells regulate bone and gut homeostasis via serotonin (5-hydroxytryptamine [5-HT]) production. A recent report suggested that gut microbes regulate 5-HT levels; however, the precise underlying molecular mechanisms are unexplored. Here, we reveal that the cation channel Pie......2020-09-24