New discovery of the pathological mechanism of alcoholic liver disease
Alcohol-associated liver disease (ALD) is a leading cause of liver injury resulting from chronic and abusive alcohol consumption. The spectrum of ALD ranges from alcoholic steatosis, to hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). A wide variety of host and environmental factors and comorbidities have been shown to modify the development and progression of ALD, including age, sex, genetic factors, drinking pattern, obesity, and chronic viral hepatitis.Despite major advances made in identifying potential pathways and therapeutic targets, there is no effective therapy besides abstinence. Uncovering novel molecular mechanisms of ALD pathogenesis that can lead to new......
Biomimic Trained Immunity-MSCs Delivery Microcarriers for Acute Liver Failure Regeneration
On 11 April 2022,Luoran Shang, Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, and his team published a paper tittled “Biomimic Trained Immunity-MSCs Delivery Microcarriers for Acute Liver Failure Regeneration” in Small, which proposed a lipopolysaccharide (LPS)-loaded photoresponsive cryogel porous microcarrier (CPM) for MSCs delivery and colonization to promote defect liver regeneration.The kits [ELISA Kit for Lipopolysaccharide (LPS), SEB526Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Mesenchymal stem cells (MSCs) have a demonstrated value for acute liver failure ......
WWC proteins mediate LATS12 activation by Hippo kinases and imply a tumor suppression strategy
On April 15, 2022, Fa-Xing Yu, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, and hia team published a paper tittled “WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy” in Molecular Cell, which uncovered a molecular mechanism underlying LATS1/2 regulation and provided a strategy for treating diverse malignancies related to Hippo pathway dysregulation.The proteins [Recombinant WW And C2 Domain Containing Protein 3 (WWC3), RPU918Hu01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.YAP and TAZ (YAP/TAZ), two major effectors of the Hippo signaling pathway, are ......
New therapeutic targets for atherosclerosis
Atherosclerosisis the leading cause of cardiovascular diseases. Endothelial dysfunction and vascular inflammation are crucial in the initiation and progression of atherosclerosis. Atherosclerosisis initiated by endothelial cells(ECs) activation through modified lipids. Activated ECs release chemokines, which allow for the recruitment of immune cells into the subendothelial space called the intima. The recruited leukocytes produce inflammatory mediators, thus augmenting the ongoing chronic inflammatory process at arterial sites, orchestrating monocyte to macrophage differentiation, foam cell formation, migration, and proliferation of smooth muscle cells. As the disease progresses, the c......
SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma
On February 23, 2022, Joanna Kopecka, Department of Oncology, University of Torino, Italy, and hia team published a paper tittled “SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma” in Journal of Experimental & Clinical Cancer Research, which proposed SKP2 as a new stratifcation marker to determine the sensitivity to cisplatin and drugs interfering with ubiquitination/proteasome systems in malignant pleural mesothelioma.The kits [ELISA Kit for High Mobility Group Protein 1 (HMGB1), SEA399Hu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchersBackground: The combination of pemetrexed and ......
22,000 Research Publications Citing Cloud-Clone Products
22,000research publications citing Cloud-Clone productsas of 2021. The amount of publications is growing at a rate of 4,000 per year. Among them, 200 publications citing our products published on Cell, Nature and Science. And there are 20 products cited in more than 100 publications.According to CiteAb, our products were cited greatlyin cancer, disease,small molecule detection and other fields. ItdemonstratedCloud-Clone product’squality and reliabilityin the research of life sciences.