The development of science and technology makes people to know the disease deeply. It was found that the etiology of many human diseases has an inseparable relationship with gene mutation. So, how to treat these diseases? People naturally think of re-editing mutant gene by using some techniques, this technology is gene editing technique. Based on protein/DNA identification and cut, gene editing techniques have been through the first generation of gene editing techniques, such as homing endonuclease, ZFN and TALEN. With the constantly understanding of the gene editing techniques, people realized the first generation of gene editing techniques have many defects, such as fussy operation, ......2017-01-09

Value-added products on the topic has continued for five, have you already had a general understanding of our value-added products? These series of topics’s writing are used to help our customers understand our product’s classification better, and find their own needs conveniently and accurately. Today we will continue to introduce three value-added products for everyone, followed by PCR Mix System, Lysis Buffer for Cells, Tissue, and Protein A/G Purification Column. The first one is PCR Mix System. PCR reagents are most widely used in bioscience research and almost all laboratories involved in molecular biology. At present, the Master Mix form of products is gradually becoming the......2016-12-15

The annual Nobel Prize holds as scheduled, and Japanese scientist Yoshinori Ohsumi was awarded this year’s Nobel Prize in Physiology or Medicine, by the discovery of cell autophagy mechanism. In the early 1950s, scientists in Belgium observed autophagic vacuole by electron microscope, and firstly put forward concept of "autophagy".Autophagy is a process of phagocytosing autologous cytoplasmic proteins or organelles, encapsulating them into vesicles and fusing with lysosomes, degrading the contents of lysosomes to achieve cellular homeostasis and organelle renewal. This procedure ended with a lysosomal closure chamber. Figure 1 graphically depicts the mechanism for autophagy......2016-12-15

Asprosin is a protein hormone that is produced by white adipose tissue in mammals, which is then transported to the liver and be stimulated for releasing of glucose into the blood stream. In the liver, asprosin activates rapid glucose release by a cAMP-dependent pathway. (Figure 1)Figure 1. Asprosin’s mode of action (Cited from cell ) This year, an article published in Cell reveals the discovery of Asprosin. The intention of this article is to study Neonatal Progeroid Syndrome (NPS), never thought in the process, they found a hormone - Asprosin, which is associated with type 2 diabetes. We will briefly introduce the discovery of this protein below. NPS is a genetic disorder, the pa......2016-12-15

With the consecutive improvement of life quality, there are more and more obese patients. According to the statistics, at least 2 million and 600 thousand people die of obesity each year. As one of the biggest killer of life, obesity can lead to a variety of metabolic diseases, including hypertension, coronary heart disease, diabetes and so on, which can seriously affect the health. In order to keep the obese people from disease, scientists pay more attention to research the mechanism and treatment of obesity. The AMPK signaling pathway can regulate the intracellular ATP supply as AMPK is an energy detector for intracellular ATP levels. Considering the central role of AMPK in regulatin......2016-12-15

Protein as the main executor of life activities,the research on its function and biological mechanism is explored in depth. So how to isolate and study a particular protein?The wide application of protein labeling technology can effectively solve this problem which makes many researchers get a headache. At present, some peptides and proteins are widely used for mass production of recombinant protein. In order to facilitate the protein expression, detection, tracing and purification, they are expressed with the target protein. This kind of polypeptide or protein is known as Protein Tag, such as MyC, His, GST, HA, etc.. The tag antibody can be highly specifically combined with the corres......2016-10-25