Circadian rhythm refers to the changes in life activities in a 24-hour cycle.In mammals, the circadian system is organized as a hierarchical oscillator network with the master pacemaker being localized in the suprachiasmatic nucleus (SCN) of the hypothalamus, which coordinates the network of peripheral tissue oscillators. The deterioration of the circadian rhythm can be the main cause of many diseases such as premature mortality, obesity, impaired glucose tolerance, diabetes, psychiatric disorders, anxiety, depression, and cancer progression, fatigue, and loss of concentration. Recently, a number of literatures have reported the mechanisms of circadian rhythm regulating metabolic disea......2022-04-22

2022-04-22

On March 21, 2022, Keiichi I. Nakayama, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, and his team published a paper tittled “Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium” in NATURE COMMUNICATIONS, which highlight a pronounced plasticity of the intestinal epithelium that supports maintenance of tissue integrity in normal and neoplastic contexts. Although the mammalian intestinal epithelium manifests robust regenerative capacity after various cytotoxic injuries, the underlying mechanism has remained unclear. Here we identify the cyclin-de......2022-04-20

Cloud-Clone Flow AntibodyAre you still worried about the long lead time of purchasing flow antibodies affecting your experiments?Are you still searching around for flow-through antibodies that match your instrument's color scheme?Are you still troubled by the low specificity of antibodies?Cloud-Clone, an original manufacturer of flow antibodies, will keep you from worrying about these things.Why choose Cloud-Clone?1. SpecificityCloud-Clone flow antibody, developed based on monoclonal technology and genetic engineering antibody technology, and verified by CRISPR-Cas9 cell knockout system.2. Fluorescent markers are more comprehensiveA variety of fluorescent markers are available, cov......2022-04-19

With the development of genetic engineering, the technology of monoclonal antibody preparation got rid of the limitation oftraditional hybridoma technology, which resolved a series of ethics problems caused by tumor mice. Compared withtraditionalpreparation technology, in aspects of species choice,antibodyscreening, titer control and mass production,genet-ic engineering antibodies show pretty advantages. Cloud-Clone Corp. provides one stop preparation service of full-lengthgenetic engineering monoclonal antibody for multiple species such as mouse, rat, rabbit, etc.2022-03-31

On Mar 1, 2022, professor Qing Jiang from Nanjing Drum Tower Hospital published a paper titled Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression on Cell Metabolism.Hepatic osteodystrophy (HOD) is a metabolic bone disease that is often associated with chronic liver disease and is marked by bone loss. Here, we demonstrate that hepatic expression of the phosphatase PP2Acα is upregulated during HOD, leading to the downregulation of expression of the hepatokine lecithin-cholesterol acyltransferase (LCAT). Loss of LCAT function markedly exacerbates the bone loss phenotype of HOD in mice. In addition, we found that alterations in cholesterol levels are inv......2022-03-30