Interferon Beta (IFNb)

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IFNB1; IFN-B; IFB; IFF; IFNB; Interferon Beta 1 Fibroblast

Interferon Beta (IFNb)

IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA222Hu01 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
RPA222Hu02 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
APA222Hu01 Active Interferon Beta (IFNb) Cell culture; Activity Assays.
Antibodies PAA222Hu01 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
MAA222Hu22 Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
PAA222Hu02 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
MAA222Hu21 Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
Assay Kits SEA222Hu ELISA Kit for Interferon Beta (IFNb) Enzyme-linked immunosorbent assay for Antigen Detection.
AEA222Hu ELISA Kit for Anti-Interferon Beta Antibody (Anti-IFNb) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA222Mu01 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
RPA222Mu02 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA222Mu01 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
PAA222Mu02 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
Assay Kits SEA222Mu ELISA Kit for Interferon Beta (IFNb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA222Ra01 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA222Ra01 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
MAA222Ra21 Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
Assay Kits SEA222Ra ELISA Kit for Interferon Beta (IFNb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA222Rb01 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA222Rb51 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
Assay Kits SEA222Rb ELISA Kit for Interferon Beta (IFNb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA222Si01 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA222Si01 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
MAA222Si21 Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
Assay Kits SEA222Si ELISA Kit for Interferon Beta (IFNb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA222Ca01 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
RPA222Ca02 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA222Ca01 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
LAA222Ca81 FITC-Linked Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IF.
LAA222Ca71 Biotin-Linked Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC.
MAA222Ca21 Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
PAA222Ca02 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
Assay Kits SEA222Ca ELISA Kit for Interferon Beta (IFNb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA222Po01 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
APA222Po01 Active Interferon Beta (IFNb) Cell culture; Activity Assays.
RPA222Po02 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
EPA222Po61 Eukaryotic Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA222Po01 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
LAA222Po81 FITC-Linked Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IF.
LAA222Po71 Biotin-Linked Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC.
MAA222Po21 Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
Assay Kits SEA222Po ELISA Kit for Interferon Beta (IFNb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA222Bo01 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA222Bo01 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
MAA222Bo21 Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
Assay Kits SEA222Bo ELISA Kit for Interferon Beta (IFNb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA222Eq01 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA222Eq01 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
MAA222Eq21 Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
Assay Kits SEA222Eq ELISA Kit for Interferon Beta (IFNb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA222Ga01 Recombinant Interferon Beta (IFNb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA222Ga01 Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
LAA222Ga71 Biotin-Linked Polyclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC.
MAA222Ga21 Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
MAA222Ga24 Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
MAA222Ga26 Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC; IP.
LAA222Ga76 Biotin-Linked Monoclonal Antibody to Interferon Beta (IFNb) WB; IHC; ICC.
Assay Kits SEA222Ga ELISA Kit for Interferon Beta (IFNb) Enzyme-linked immunosorbent assay for Antigen Detection.
HEA222Ga High Sensitive ELISA Kit for Interferon Beta (IFNb) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human fibroblast interferon gene lacks introns."Nucleic Acids Res. 9:1045-1052(1981) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of a chromosomal gene for human interferon beta."Proc. Natl. Acad. Sci. U.S.A. 78:5305-5309(1981) [PubMed] [Europe PMC] [Abstract]
  3. "The nucleotide sequence of human fibroblast interferon cDNA."Gene 10:11-15(1980) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation and structure of a human fibroblast interferon gene."Nature 285:542-547(1980) [PubMed] [Europe PMC] [Abstract]
  5. "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase."Nucleic Acids Res. 8:2885-2894(1980) [PubMed] [Europe PMC] [Abstract]
  6. "Synthesis of human fibroblast interferon by E. coli."Nucleic Acids Res. 8:4057-4074(1980) [PubMed] [Europe PMC] [Abstract]
  7. "On the relationship between human interferon alpha 1 and beta 1 genes."J. Interferon Res. 5:521-526(1985) [PubMed] [Europe PMC] [Abstract]
  8. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers."Nucleic Acids Res. 8:1913-1931(1980) [PubMed] [Europe PMC] [Abstract]
  11. "Assignment of the disulphide bonds of leukocyte interferon."Nature 289:606-607(1981) [PubMed] [Europe PMC] [Abstract]
  12. "A single amino acid change in IFN-beta1 abolishes its antiviral activity."Nature 294:563-565(1981) [PubMed] [Europe PMC] [Abstract]
  13. "The crystal structure of human interferon beta at 2.2-A resolution."Proc. Natl. Acad. Sci. U.S.A. 94:11813-11818(1997) [PubMed] [Europe PMC] [Abstract]
  14. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]