Neuromedin B (NMB)

Neuromedin B (NMB) is a bombesin-related peptide in mammals. It was originally purified from pig spinal cord, and later shown to be present in human central nervous system and gastrointestinal tract. NMB acts by binding to its high affinity cell surface receptor, neuromedin B receptor (NMBR). This receptor is a G protein-coupled receptor with seven transmembrane spanning regions, hence the receptor is also denoted as a 7-transmembrane receptor (7-TMR). Upon binding several intracellular signaling pathways are triggered.

When NMB binds to its 7-TMR, the heterotrimeric G protein that is attached to the receptor is activated. The G-protein is called heterotrimeric because it consists of 3 polypeptides: α subunit, β subunit, and γ subunit.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA803Hu01 Recombinant Neuromedin B (NMB) Positive Control; Immunogen; SDS-PAGE; WB.
CPA803Hu21 OVA Conjugated Neuromedin B (NMB) Immunogen; SDS-PAGE; WB.
Antibodies PAA803Hu01 Polyclonal Antibody to Neuromedin B (NMB) WB; IHC; ICC; IP.
MAA803Hu22 Monoclonal Antibody to Neuromedin B (NMB) WB; IHC; ICC; IP.
Assay Kits CEA803Hu ELISA Kit for Neuromedin B (NMB) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA803Hu ELISA Kit for Neuromedin B (NMB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA803Mu01 Recombinant Neuromedin B (NMB) Positive Control; Immunogen; SDS-PAGE; WB.
RPA803Mu02 Recombinant Neuromedin B (NMB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA803Mu01 Polyclonal Antibody to Neuromedin B (NMB) WB; IHC; ICC; IP.
MAA803Mu22 Monoclonal Antibody to Neuromedin B (NMB) WB; IHC; ICC; IP.
PAA803Mu02 Polyclonal Antibody to Neuromedin B (NMB) WB; IHC; ICC; IP.
Assay Kits CEA803Mu ELISA Kit for Neuromedin B (NMB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA803Ra01 Recombinant Neuromedin B (NMB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA803Ra01 Polyclonal Antibody to Neuromedin B (NMB) WB; IHC; ICC; IP.
MAA803Ra21 Monoclonal Antibody to Neuromedin B (NMB) WB; IHC; ICC; IP.
Assay Kits CEA803Ra ELISA Kit for Neuromedin B (NMB) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin."J. Biol. Chem. 263:13317-13323(1988) [PubMed] [Europe PMC] [Abstract]
  2. ErratumJ. Biol. Chem. 265:7091-7091(1990)
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy."FEBS Lett. 460:263-269(1999) [PubMed] [Europe PMC] [Abstract]