≡

Prostaglandin E Synthase 2 (PTGES2)

[Edit]

C9orf15; PGES2; mPGES-2; Chromosome 9 Open Reading Frame 15; Microsomal prostaglandin E synthase 2; Prostaglandin E synthase 2 truncated form

Prostaglandin E Synthase 2 (PTGES2)
CCC A905
HGNC 17822
MGI 1917592
PubMed 17979097
RGD 1310836
UniProt Q9H7Z7
Wiki PTGES2

  • PTGES2 catalyzes the conversion of prostaglandin H2 to prostaglandin E2 (Tanikawa et al). It also activates transcription from a gamma-interferon (IFNG)-activated transcriptional element, or GATE.

  • Tanikawa et al. (2002) identified monkey and human cDNAs encoding proteins homologous to Ptges2 purified from the microsomal fraction of bovine heart. The monkey and human cDNAs encode 377-amino acid proteins that share 97% identity. Both proteins have 87 additional N-terminal amino acids compared with the purified bovine Ptges2, and they both have a consensus region shared with glutaredoxin and thioredoxin.Hu et al. (2002) cloned mouse Ptges2, which they designated Gbf1. The deduced protein contains 384 amino acids and has a calculated molecular mass of about 38 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA905Hu01 Recombinant Prostaglandin E Synthase 2 (PTGES2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA905Hu01 Polyclonal Antibody to Prostaglandin E Synthase 2 (PTGES2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Prostaglandin E Synthase 2 (PTGES2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin E Synthase 2 (PTGES2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA905Mu01 Recombinant Prostaglandin E Synthase 2 (PTGES2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA905Mu01 Polyclonal Antibody to Prostaglandin E Synthase 2 (PTGES2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Prostaglandin E Synthase 2 (PTGES2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin E Synthase 2 (PTGES2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostaglandin E Synthase 2 (PTGES2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostaglandin E Synthase 2 (PTGES2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin E Synthase 2 (PTGES2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostaglandin E Synthase 2 (PTGES2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin E Synthase 2 (PTGES2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of a novel type of membrane-associated prostaglandin E synthase."Biochem. Biophys. Res. Commun. 291:884-889(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2."Biochem. Biophys. Res. Commun. 306:577-581(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2."J. Biol. Chem. 278:37937-37947(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A protein interaction framework for human mRNA degradation."Genome Res. 14:1315-1323(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Studies on membrane-associated prostaglandin E synthase-2 with reference to production of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT)."Biochem. Biophys. Res. Commun. 367:782-786(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]