Surfactant Associated Protein D (SPD)

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SFTPD; COLEC7; PSP-D; SFTP4; SP-D; Pulmonary Surfactant Protein D; Collectin-7; Lung surfactant protein D

Surfactant Associated Protein D (SPD)

Surfactant protein D (SP-D) belongs to the collectin family.These proteins are oligomeric proteins composed of carbohydrate-recognition domains(CRD)attached to collagenous regions.Collectins are structurally similar to the ficolins although they make use of different CRD structures:C-type lectin domain for the collectins.The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type Ⅱcells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointestinal tract and in epithelial cells of various exocrine glands. SP-D is an important factor in the pulmonary anti-microbial defense. The anti-microbial defense mechanisms of SP-D are direct opsonization, neutralization and agglutination.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB039Hu01 Recombinant Surfactant Associated Protein D (SPD) Positive Control; Immunogen; SDS-PAGE; WB.
EPB039Hu61 Eukaryotic Surfactant Associated Protein D (SPD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB039Hu01 Polyclonal Antibody to Surfactant Associated Protein D (SPD) WB; IHC; ICC; IP.
MAB039Hu22 Monoclonal Antibody to Surfactant Associated Protein D (SPD) WB; IHC; ICC; IP.
LAB039Hu71 Biotin-Linked Polyclonal Antibody to Surfactant Associated Protein D (SPD) WB; IHC; ICC.
LAB039Hu81 FITC-Linked Polyclonal Antibody to Surfactant Associated Protein D (SPD) WB; IHC; ICC; IF.
Assay Kits SEB039Hu ELISA Kit for Surfactant Associated Protein D (SPD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB039Mu01 Recombinant Surfactant Associated Protein D (SPD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB039Mu02 Recombinant Surfactant Associated Protein D (SPD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB039Mu01 Polyclonal Antibody to Surfactant Associated Protein D (SPD) WB; IHC; ICC; IP.
PAB039Mu02 Polyclonal Antibody to Surfactant Associated Protein D (SPD) WB; IHC; ICC; IP.
LAB039Mu71 Biotin-Linked Polyclonal Antibody to Surfactant Associated Protein D (SPD) WB; IHC; ICC.
Assay Kits SEB039Mu ELISA Kit for Surfactant Associated Protein D (SPD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB039Ra01 Recombinant Surfactant Associated Protein D (SPD) Positive Control; Immunogen; SDS-PAGE; WB.
EPB039Ra61 Eukaryotic Surfactant Associated Protein D (SPD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB039Ra01 Polyclonal Antibody to Surfactant Associated Protein D (SPD) WB; IHC; ICC; IP.
LAB039Ra71 Biotin-Linked Polyclonal Antibody to Surfactant Associated Protein D (SPD) WB; IHC; ICC.
LAB039Ra81 FITC-Linked Polyclonal Antibody to Surfactant Associated Protein D (SPD) WB; IHC; ICC; IF.
MAB039Ra21 Monoclonal Antibody to Surfactant Associated Protein D (SPD) WB; IHC; ICC; IP.
Assay Kits SEB039Ra ELISA Kit for Surfactant Associated Protein D (SPD) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Purification, characterization and cDNA cloning of human lung surfactant protein D."Biochem. J. 284:795-802(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1."J. Biol. Chem. 268:2976-2983(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Accumulation of surfactant protein D in human pulmonary alveolar proteinosis."Am. J. Pathol. 142:241-248(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain."Arch. Biochem. Biophys. 290:116-126(1991) [PubMed] [Europe PMC] [Abstract]
  7. "The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status."Int. J. Obes. Relat. Metab. Disord. 37:1532-1538(2013) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D."Structure 7:255-264(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer."Am. J. Hum. Genet. 84:52-59(2009) [PubMed] [Europe PMC] [Abstract]