Tryptase (TPS)

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TPSAB1; Tryptase Alpha/Beta 1; Tryptase Alpha II; Tryptase Beta I; Tryptase-I; Tryptase-II; Tryptase-III

Tryptase (TPS)
  • Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells that has recently been used as a marker for mast cell activation. It is involved with allergenic response and is suspected to act as a mitogen for fibroblast lines. Elevated levels of serum tryptase occur in both anaphylactic and anaphylactoid reactions, but a negative test does not exclude anaphylaxis.

  • Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB070Hu01 Recombinant Tryptase (TPS) Positive Control; Immunogen; SDS-PAGE; WB.
RPB070Hu02 Recombinant Tryptase (TPS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB070Hu01 Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
MAB070Hu22 Monoclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
LAB070Hu71 Biotin-Linked Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC.
MAB070Hu24 Monoclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
MAB070Hu26 Monoclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
LAB070Hu76 Biotin-Linked Monoclonal Antibody to Tryptase (TPS) WB; IHC; ICC.
MAB070Hu21 Monoclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
Assay Kits SEB070Hu ELISA Kit for Tryptase (TPS) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB070Hu CLIA Kit for Tryptase (TPS) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB070Mu01 Recombinant Tryptase (TPS) Positive Control; Immunogen; SDS-PAGE; WB.
RPB070Mu02 Recombinant Tryptase (TPS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB070Mu01 Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
LAB070Mu71 Biotin-Linked Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC.
PAB070Mu02 Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
Assay Kits SEB070Mu ELISA Kit for Tryptase (TPS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB070Ra01 Recombinant Tryptase (TPS) Positive Control; Immunogen; SDS-PAGE; WB.
RPB070Ra02 Recombinant Tryptase (TPS) Positive Control; Immunogen; SDS-PAGE; WB.
RPB070Ra03 Recombinant Tryptase (TPS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB070Ra01 Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
PAB070Ra02 Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
LAB070Ra71 Biotin-Linked Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC.
Assay Kits SEB070Ra ELISA Kit for Tryptase (TPS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB070Ca01 Recombinant Tryptase (TPS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB070Ca01 Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
LAB070Ca71 Biotin-Linked Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC.
MAB070Ca21 Monoclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
Assay Kits SEB070Ca ELISA Kit for Tryptase (TPS) Enzyme-linked immunosorbent assay for Antigen Detection.
HEB070Ca High Sensitive ELISA Kit for Tryptase (TPS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB070Po01 Recombinant Tryptase (TPS) Positive Control; Immunogen; SDS-PAGE; WB.
RPB070Po02 Recombinant Tryptase (TPS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB070Po01 Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
MAB070Po21 Monoclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
Assay Kits SEB070Po ELISA Kit for Tryptase (TPS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB070Eq01 Recombinant Tryptase (TPS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB070Eq01 Polyclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
MAB070Eq21 Monoclonal Antibody to Tryptase (TPS) WB; IHC; ICC; IP.
Assay Kits SEB070Eq ELISA Kit for Tryptase (TPS) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and characterization of complementary DNA for human tryptase."J. Clin. Invest. 84:1188-1195(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family."Proc. Natl. Acad. Sci. U.S.A. 87:3811-3815(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3."J. Biol. Chem. 274:3355-3362(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations."J. Allergy Clin. Immunol. 124:1099-1105(2009) [PubMed] [Europe PMC] [Abstract]
  5. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates."J. Biol. Chem. 262:1363-1373(1987) [PubMed] [Europe PMC] [Abstract]
  8. "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."Blood 103:2710-2717(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Active monomers of human beta-tryptase have expanded substrate specificities."Int. Immunopharmacol. 7:1900-1908(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  11. "The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region."J. Mol. Biol. 321:491-502(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog."Pharmacogenetics 10:389-396(2000) [PubMed] [Europe PMC] [Abstract]