Nucleoporin 88 (NUP88)

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Nuclear pore complex protein Nup88; Nucleoporin 88kDa

Nucleoporin 88 (NUP88)

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. 

NUP88 is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Fornerod et al. (1997) found that the NUP88 cDNA predicted a protein of 741 amino acids with a molecular mass of 85 kD. The protein migrated at 88 kD and was therefore named NUP88 to distinguish it from NUP85.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB198Hu01 Recombinant Nucleoporin 88 (NUP88) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB198Hu01 Polyclonal Antibody to Nucleoporin 88 (NUP88) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nucleoporin 88 (NUP88) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 88 (NUP88) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB198Mu01 Recombinant Nucleoporin 88 (NUP88) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB198Mu01 Polyclonal Antibody to Nucleoporin 88 (NUP88) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nucleoporin 88 (NUP88) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 88 (NUP88) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB198Ra01 Recombinant Nucleoporin 88 (NUP88) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB198Ra01 Polyclonal Antibody to Nucleoporin 88 (NUP88) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nucleoporin 88 (NUP88) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoporin 88 (NUP88) ELISA Kit Customized Service Offer
  1. "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88."EMBO J. 16:807-816(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  4. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]