Protein O-Fucosyltransferase 1 (POFUT1)

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O-FUT; O-Fuc-T; FUT12; GDP-Fucose Protein O-Fucosyltransferase 1; Peptide-O-fucosyltransferase 1

Protein O-Fucosyltransferase 1 (POFUT1)

-fucosyltransferase 1 (POFUT1) is an enzyme responsible for adding fucose sugars in O linkage to serine or threonine residues between the second and third conserved cysteines in EGF-like repeats on the Notch protein. The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-beta-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-alpha-O-serine/threonine.

When the gene for POFUT1 is knocked out, or the expression is decreased to very low levels, all Notch signaling is destroyed, which means that fucose on Notch is absolutely essential for Notch function. Why this is the case is not yet well understood.Almost all glycosyltransferases reside in the Golgi apparatus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC072Hu01 Recombinant Protein O-Fucosyltransferase 1 (POFUT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC072Hu01 Polyclonal Antibody to Protein O-Fucosyltransferase 1 (POFUT1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein O-Fucosyltransferase 1 (POFUT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein O-Fucosyltransferase 1 (POFUT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC072Mu01 Recombinant Protein O-Fucosyltransferase 1 (POFUT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC072Mu01 Polyclonal Antibody to Protein O-Fucosyltransferase 1 (POFUT1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein O-Fucosyltransferase 1 (POFUT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein O-Fucosyltransferase 1 (POFUT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein O-Fucosyltransferase 1 (POFUT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein O-Fucosyltransferase 1 (POFUT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein O-Fucosyltransferase 1 (POFUT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein O-Fucosyltransferase 1 (POFUT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein O-Fucosyltransferase 1 (POFUT1) ELISA Kit Customized Service Offer
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  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in POFUT1, encoding protein O-fucosyltransferase 1, cause generalized Dowling-Degos disease."Am. J. Hum. Genet. 92:895-903(2013) [PubMed] [Europe PMC] [Abstract]