Calcium Modulating Ligand (CAMLG)

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CAML; Calcium Signal-Modulating Cyclophilin Ligand; Calcium-Signal Modulating Cyclophilin Ligand; Cyclophilin B-Binding Protein

Calcium Modulating Ligand (CAMLG)

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin.

Calcium signal-modulating cyclophilin ligand functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC356Hu01 Recombinant Calcium Modulating Ligand (CAMLG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC356Hu01 Polyclonal Antibody to Calcium Modulating Ligand (CAMLG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcium Modulating Ligand (CAMLG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Modulating Ligand (CAMLG) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC356Mu01 Recombinant Calcium Modulating Ligand (CAMLG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC356Mu01 Polyclonal Antibody to Calcium Modulating Ligand (CAMLG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcium Modulating Ligand (CAMLG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Modulating Ligand (CAMLG) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC356Ra01 Recombinant Calcium Modulating Ligand (CAMLG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC356Ra01 Polyclonal Antibody to Calcium Modulating Ligand (CAMLG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcium Modulating Ligand (CAMLG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Modulating Ligand (CAMLG) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis."J. Virol. 76:11491-11504(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]