150 kDa Oxygen Regulated Protein (ORP150)

[Edit]

HYOU1; HSP12A; Grp170; Glucose-Regulated Protein 170; Hypoxia Up Regulated 1

150 kDa Oxygen Regulated Protein (ORP150)

HYOU1 is a protein  belongs to the heat shock protein 70 family. This gene has three mRNAs from the use of alternative transcription sites. A cis-acting segment is found at the 5' end of exon 1A which is involved in the stress-dependent induction. The transcript that begins with exon 1B is preferentially induced by hypoxia, resulting in the accumulation of this protein in the endoplasmic reticulum (ER). The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC537Hu01 Recombinant 150 kDa Oxygen Regulated Protein (ORP150) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC537Hu01 Polyclonal Antibody to 150 kDa Oxygen Regulated Protein (ORP150) WB; IHC; ICC; IP.
MAC537Hu22 Monoclonal Antibody to 150 kDa Oxygen Regulated Protein (ORP150) WB; IHC; ICC; IP.
LAC537Hu71 Biotin-Linked Polyclonal Antibody to 150 kDa Oxygen Regulated Protein (ORP150) WB; IHC; ICC.
LAC537Hu81 FITC-Linked Polyclonal Antibody to 150 kDa Oxygen Regulated Protein (ORP150) WB; IHC; ICC; IF.
Assay Kits SEC537Hu ELISA Kit for 150 kDa Oxygen Regulated Protein (ORP150) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 150 kDa Oxygen Regulated Protein (ORP150) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 150 kDa Oxygen Regulated Protein (ORP150) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 150 kDa Oxygen Regulated Protein (ORP150) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 150 kDa Oxygen Regulated Protein (ORP150) CLIA Kit Customized Service Offer
n/a ELISA Kit for 150 kDa Oxygen Regulated Protein (ORP150) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 150 kDa Oxygen Regulated Protein (ORP150) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 150 kDa Oxygen Regulated Protein (ORP150) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 150 kDa Oxygen Regulated Protein (ORP150) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 150 kDa Oxygen Regulated Protein (ORP150) CLIA Kit Customized Service Offer
n/a ELISA Kit for 150 kDa Oxygen Regulated Protein (ORP150) ELISA Kit Customized Service Offer
  1. "Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150."Biochem. Biophys. Res. Commun. 230:94-99(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Production of three distinct mRNAs of 150 kDa oxygen-regulated protein (ORP150) by alternative promoters: preferential induction of one species under stress conditions."J. Biochem. 128:529-538(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone."Protein J. 25:517-528(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]