Lysyl Oxidase (LOX)

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Protein-Lysine 6-Oxidase

Lysyl Oxidase (LOX)
Lysyl oxidase is a protein. Its inhibition can cause lathyrism, but at the same time, its upregulation by tumor cells may promote metastasis of the existing tumor, causing it to become malignant and cancerous.Lysyl oxidase is an extracellular copper enzyme that catalyzes formation of aldehydes from lysine residues in collagen and elastin precursors.These aldehydes are highly reactive, and undergo spontaneous chemical reactions with other lysyl oxidase-derived aldehyde residues, or with unmodified lysine residues. This results in cross-linking collagen and elastin, which is essential for stabilization of collagen fibrils and for the integrity and elasticity of mature elastin.Complex cross-links are formed in collagen and in elastin that differ in structure.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC580Hu01 Recombinant Lysyl Oxidase (LOX) Positive Control; Immunogen; SDS-PAGE; WB.
APC580Hu01 Active Lysyl Oxidase (LOX) Cell culture; Activity Assays.
RPC580Hu02 Recombinant Lysyl Oxidase (LOX) Positive Control; Immunogen; SDS-PAGE; WB.
EPC580Hu61 Eukaryotic Lysyl Oxidase (LOX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC580Hu01 Polyclonal Antibody to Lysyl Oxidase (LOX) WB; IHC; ICC; IP.
MAC580Hu22 Monoclonal Antibody to Lysyl Oxidase (LOX) WB; IHC; ICC; IP.
LAC580Hu81 FITC-Linked Polyclonal Antibody to Lysyl Oxidase (LOX) WB; IHC; ICC; IF.
LAC580Hu71 Biotin-Linked Polyclonal Antibody to Lysyl Oxidase (LOX) WB; IHC; ICC.
Assay Kits SEC580Hu ELISA Kit for Lysyl Oxidase (LOX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC580Mu01 Recombinant Lysyl Oxidase (LOX) Positive Control; Immunogen; SDS-PAGE; WB.
RPC580Mu02 Recombinant Lysyl Oxidase (LOX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC580Mu01 Polyclonal Antibody to Lysyl Oxidase (LOX) WB; IHC; ICC; IP.
LAC580Mu81 FITC-Linked Polyclonal Antibody to Lysyl Oxidase (LOX) WB; IHC; ICC; IF.
LAC580Mu71 Biotin-Linked Polyclonal Antibody to Lysyl Oxidase (LOX) WB; IHC; ICC.
PAC580Mu02 Polyclonal Antibody to Lysyl Oxidase (LOX) WB; IHC; ICC; IP.
Assay Kits SEC580Mu ELISA Kit for Lysyl Oxidase (LOX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysyl Oxidase (LOX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysyl Oxidase (LOX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysyl Oxidase (LOX) Polyclonal Antibody Customized Service Offer
Assay Kits SEC580Ra ELISA Kit for Lysyl Oxidase (LOX) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2."Genomics 11:508-516(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene)."Matrix 12:242-248(1992) [PubMed] [Europe PMC] [Abstract]
  3. "A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase."J. Biol. Chem. 270:7176-7182(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene."Mol. Cell. Biochem. 194:79-91(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of the human lysyl oxidase gene."Genomics 17:544-548(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of the human lysyl oxidase gene locus."J. Biol. Chem. 267:14382-14387(1992) [PubMed] [Europe PMC] [Abstract]
  9. "A restriction fragment length polymorphism results in a nonconservative amino acid substitution encoded within the first exon of the human lysyl oxidase gene."Genomics 16:401-406(1993) [PubMed] [Europe PMC] [Abstract]