Pericentrin (PCNT)


KEN; PCN; PCNT2; PCNTB; PCTN2; SCKL4; Kendrin; Seckel Syndrome 4; Pericentrin-B

Pericentrin (PCNT)
Pericentrin (kendrin), also known as PCNT, is a protein binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM).
The protein contains a series of coiled coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component γ-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell cycle progression.Expressed in all tissues tested, including placenta, liver, kidney and thymus. pericentrin is a conserved integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays.

Organism species: Homo sapiens (Human)

Proteins RPC716Hu01 Recombinant Pericentrin (PCNT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC716Hu01 Polyclonal Antibody to Pericentrin (PCNT) WB; IHC; ICC; IP.
Assay Kits SEC716Hu ELISA Kit for Pericentrin (PCNT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

Proteins RPC716Mu01 Recombinant Pericentrin (PCNT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Pericentrin (PCNT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pericentrin (PCNT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pericentrin (PCNT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pericentrin (PCNT) ELISA Kit Customized Service Offer
  1. "Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1."J. Cell Sci. 114:797-809(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin."Proc. Natl. Acad. Sci. U.S.A. 97:5919-5923(2000) [PubMed] [Europe PMC] [Abstract]
  7. "DISC1-kendrin interaction is involved in centrosomal microtubule network formation."Biochem. Biophys. Res. Commun. 377:1051-1056(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling."Nat. Genet. 40:232-236(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in the pericentrin (PCNT) gene cause primordial dwarfism." Science 319:816-819(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Involvement of a centrosomal protein kendrin in the maintenance of centrosome cohesion by modulating Nek2A kinase activity."Biochem. Biophys. Res. Commun. 398:217-223(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex."J. Biol. Chem. 285:22658-22665(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "The centriolar satellite protein Cep131 is important for genome stability."J. Cell Sci. 125:4770-4779(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability."J. Cell Sci. 127:2910-2919(2014) [PubMed] [Europe PMC] [Abstract]