Aminoadipate Semialdehyde Synthase (AASS)

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LKR/SDH; LKRSDH; LORSDH; Saccharopine dehydrogenase; Alpha-Aminoadipic Semialdehyde Synthase,Mitochondrial; Lysine ketoglutarate reductase

Aminoadipate Semialdehyde Synthase (AASS)
Alpha-aminoadipic semialdehyde synthase, mitochondrial is a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia.
This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC855Hu01 Recombinant Aminoadipate Semialdehyde Synthase (AASS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC855Hu01 Polyclonal Antibody to Aminoadipate Semialdehyde Synthase (AASS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Aminoadipate Semialdehyde Synthase (AASS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminoadipate Semialdehyde Synthase (AASS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC855Mu01 Recombinant Aminoadipate Semialdehyde Synthase (AASS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC855Mu01 Polyclonal Antibody to Aminoadipate Semialdehyde Synthase (AASS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Aminoadipate Semialdehyde Synthase (AASS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminoadipate Semialdehyde Synthase (AASS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aminoadipate Semialdehyde Synthase (AASS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aminoadipate Semialdehyde Synthase (AASS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aminoadipate Semialdehyde Synthase (AASS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aminoadipate Semialdehyde Synthase (AASS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminoadipate Semialdehyde Synthase (AASS) ELISA Kit Customized Service Offer
  1. "Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia."Am. J. Hum. Genet. 66:1736-1743(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  4. "Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia."Hum. Mol. Genet. 23:5009-5016(2014) [PubMed] [Europe PMC] [Abstract]
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]