Tryptase Beta 2 (TPSb2)

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TPS2; Tryptase Beta II; Tryptase Beta III

Tryptase Beta 2 (TPSb2)
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors.
TPSb2 is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD781Hu01 Recombinant Tryptase Beta 2 (TPSb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD781Hu01 Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
LAD781Hu71 Biotin-Linked Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC.
MAD781Hu21 Monoclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
LAD781Hu81 FITC-Linked Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IF.
Assay Kits SED781Hu ELISA Kit for Tryptase Beta 2 (TPSb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD781Mu01 Recombinant Tryptase Beta 2 (TPSb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD781Mu01 Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tryptase Beta 2 (TPSb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tryptase Beta 2 (TPSb2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD781Ra01 Recombinant Tryptase Beta 2 (TPSb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD781Ra01 Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tryptase Beta 2 (TPSb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tryptase Beta 2 (TPSb2) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a second complementary DNA for human tryptase."J. Clin. Invest. 86:864-870(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of a tryptase mRNA expressed in the human basophil cell line KU812."Scand. J. Immunol. 37:203-208(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3."J. Biol. Chem. 274:3355-3362(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations."J. Allergy Clin. Immunol. 124:1099-1105(2009) [PubMed] [Europe PMC] [Abstract]
  5. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family."Proc. Natl. Acad. Sci. U.S.A. 87:3811-3815(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."Blood 103:2710-2717(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Active monomers of human beta-tryptase have expanded substrate specificities."Int. Immunopharmacol. 7:1900-1908(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Human beta-tryptase is a ring-like tetramer with active sites facing a central pore."Nature 392:306-311(1998) [PubMed] [Europe PMC] [Abstract]
  11. "The structure of the human betaII-tryptase tetramer: fo(u)r better or worse."Proc. Natl. Acad. Sci. U.S.A. 96:10984-10991(1999) [PubMed] [Europe PMC] [Abstract]