Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2)

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TLH; LH2; Telopeptide Lysyl Hydroxylase; Lysyl hydroxylase 2

Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2)
PLOD2 is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. The similarity is even higher in the C-terminal region of the polypeptides. The PLOD2 gene contains 9 cysteines conserved in PLOD, in addition to conserved histidines in the putative active site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE257Hu01 Recombinant Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE257Hu21 Monoclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) WB; IHC; ICC; IP.
PAE257Hu01 Polyclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) WB; IHC; ICC; IP.
Assay Kits SEE257Hu ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 2 (PLOD2) ELISA Kit Customized Service Offer
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  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis."J. Biol. Chem. 278:40967-40972(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Phenotypic and molecular characterization of Bruck syndrome (osteogenesis imperfecta with contractures of the large joints) caused by a recessive mutation in PLOD2."Am. J. Med. Genet. A 131:115-120(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in PLOD2 cause autosomal-recessive connective tissue disorders within the Bruck syndrome--osteogenesis imperfecta phenotypic spectrum."Hum. Mutat. 33:1444-1449(2012) [PubMed] [Europe PMC] [Abstract]