Bromodomain Containing Protein 2 (BRD2)

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FSRG1; NAT; RING3; RNF3; Really interesting new gene 3 protein

Bromodomain Containing Protein 2 (BRD2)
BRD2 is encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene, but the full-length nature of some of these variants has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF132Hu01 Recombinant Bromodomain Containing Protein 2 (BRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Bromodomain Containing Protein 2 (BRD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain Containing Protein 2 (BRD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain Containing Protein 2 (BRD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain Containing Protein 2 (BRD2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain Containing Protein 2 (BRD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain Containing Protein 2 (BRD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain Containing Protein 2 (BRD2) Polyclonal Antibody Customized Service Offer
Assay Kits SEF132Mu ELISA Kit for Bromodomain Containing Protein 2 (BRD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain Containing Protein 2 (BRD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain Containing Protein 2 (BRD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain Containing Protein 2 (BRD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain Containing Protein 2 (BRD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain Containing Protein 2 (BRD2) ELISA Kit Customized Service Offer
  1. "A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC."DNA Seq. 2:203-210(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Phylogeny and structure of the RING3 gene."Immunogenetics 44:391-396(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription."Mol. Cell 30:51-60(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone h4."J. Biol. Chem. 282:4193-4201(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Selective inhibition of BET bromodomains." Nature 468:1067-1073(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]