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Adaptor Related Protein Complex 3 Beta 1 (AP3b1)

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HPS; PE; HPS2; ADTB3; ADTB3A; Clathrin assembly protein complex 3 beta-1 large chain; Adaptor protein complex AP-3 subunit beta-1

Adaptor Related Protein Complex 3 Beta 1 (AP3b1)
CCC G109
HGNC 566
MGI 1333879
PubMed 23557002
RGD 1310256
UniProt O00203
Wiki AP3B1
AP3b1 encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes.
The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. The 1,094-amino acid beta-3A-adaptin protein shares 61% identity with beta-NAP and is also related to the beta-1- (AP1B1) and beta-2-adaptin (AP2B1) subunits of complexes AP1 and AP2, respectively. The central hydrophilic region of beta-3A-adaptin is rich in acidic and serine residues and contains many potential sites for phosphorylation; the authors demonstrated that beta-3A-adaptin is phosphorylated in vivo on serine residues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG109Hu01 Recombinant Adaptor Related Protein Complex 3 Beta 1 (AP3b1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 3 Beta 1 (AP3b1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 3 Beta 1 (AP3b1) Polyclonal Antibody Customized Service Offer
Assay Kits SEG109Hu ELISA Kit for Adaptor Related Protein Complex 3 Beta 1 (AP3b1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 3 Beta 1 (AP3b1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 3 Beta 1 (AP3b1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 3 Beta 1 (AP3b1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 3 Beta 1 (AP3b1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 3 Beta 1 (AP3b1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 3 Beta 1 (AP3b1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 3 Beta 1 (AP3b1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 3 Beta 1 (AP3b1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 3 Beta 1 (AP3b1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 3 Beta 1 (AP3b1) ELISA Kit Customized Service Offer
  1. "Characterization of the adaptor-related protein complex, AP-3."J. Cell Biol. 137:835-845(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3."J. Biol. Chem. 272:15078-15084(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor."Mol. Cell 3:11-21(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]