Ring Box Protein 1 (RBX1)

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ROC1; RNF75; Regulator Of Cullins 1; E3 ubiquitin-protein ligase RBX1; Protein ZYP; RING finger protein 75; Regulator of cullins 1

Ring Box Protein 1 (RBX1)
RING-box protein 1 plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over.The ROC1 and ROC2 proteins commonly interact with all cullins. Yeast ROC1 encodes an essential gene whose reduced expression resulted in multiple, elongated buds and accumulation of Sic1 and Cln2 proteins.
ROC1 and APC11 immunocomplexes can catalyze isopeptide ligations to form polyubiquitin chains in an E1- and E2-dependent manner. ROC1 mutations completely abolished their ligase activity without noticeable changes in associated proteins. Ubiquitination of phosphorylated I-kappa-B-alpha can be catalyzed by the ROC1 immunocomplex in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG674Hu01 Recombinant Ring Box Protein 1 (RBX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG674Hu21 Monoclonal Antibody to Ring Box Protein 1 (RBX1) WB; IHC; ICC; IP.
MAG674Hu22 Monoclonal Antibody to Ring Box Protein 1 (RBX1) WB; IHC; ICC; IP.
MAG674Hu23 Monoclonal Antibody to Ring Box Protein 1 (RBX1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ring Box Protein 1 (RBX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Box Protein 1 (RBX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Box Protein 1 (RBX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Box Protein 1 (RBX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Box Protein 1 (RBX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Box Protein 1 (RBX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Box Protein 1 (RBX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Box Protein 1 (RBX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Box Protein 1 (RBX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Box Protein 1 (RBX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Box Protein 1 (RBX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Box Protein 1 (RBX1) ELISA Kit Customized Service Offer
  1. "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity."Mol. Cell 3:535-541(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase."Science 284:657-661(1999) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]