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TANK Binding Kinase 1 (TBK1)

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NAK; T2K; NF-kappa-B-activating kinase; Serine/threonine-protein kinase TBK1

TANK Binding Kinase 1 (TBK1)
CCC H061
HGNC 11584
MGI 1929658
PubMed 21329883
RGD 1588588
UniProt Q9UHD2
Wiki TBK1
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. TANK-Binding Kinase 1 is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.The cDNA encodes a deduced 730-amino acid protein that contains a leucine zipper and a helix-loop-helix motif within its C-terminal half. Unlike IKBKA and IKBKB, which each contain 2 serines in their respective activation loops, NAK contains a glutamic acid (glu168) and a serine, which must be phosphorylated for activation. Northern blot analysis revealed ubiquitous expression of a 2.2-kb transcript, with highest expression in testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH061Hu01 Recombinant TANK Binding Kinase 1 (TBK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH061Hu21 Monoclonal Antibody to TANK Binding Kinase 1 (TBK1) WB; IHC; ICC; IP.
PAH061Hu01 Polyclonal Antibody to TANK Binding Kinase 1 (TBK1) WB; IHC; ICC; IP.
Assay Kits SEH061Hu ELISA Kit for TANK Binding Kinase 1 (TBK1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH061Mu01 Recombinant TANK Binding Kinase 1 (TBK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to TANK Binding Kinase 1 (TBK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TANK Binding Kinase 1 (TBK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TANK Binding Kinase 1 (TBK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TANK Binding Kinase 1 (TBK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TANK Binding Kinase 1 (TBK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TANK Binding Kinase 1 (TBK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TANK Binding Kinase 1 (TBK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TANK Binding Kinase 1 (TBK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TANK Binding Kinase 1 (TBK1) ELISA Kit Customized Service Offer
  1. "NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase."EMBO J. 18:6694-6704(1999) [PubMed] [Europe PMC] [Abstract]
  2. "NAK is an IkappaB kinase-activating kinase."Nature 404:778-782(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2."J. Biol. Chem. 277:13840-13847(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling."J. Immunol. 171:4304-4310(2003) [PubMed] [Europe PMC] [Abstract]
  7. "IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway."Nat. Immunol. 4:491-496(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Triggering the interferon antiviral response through an IKK-related pathway."Science 300:1148-1151(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling."Mol. Cell. Biol. 23:7780-7793(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation."J. Biol. Chem. 279:9698-9702(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."J. Biol. Chem. 279:15652-15661(2004) [PubMed] [Europe PMC] [Abstract]
  12. "NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach."J. Biol. Chem. 279:53266-53271(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription."J. Biol. Chem. 279:55633-55643(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity."J. Virol. 78:10636-10649(2004) [PubMed] [Europe PMC] [Abstract]
  15. "SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways."EMBO J. 24:4018-4028(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses."Hepatology 41:1004-1012(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Viral targeting of the interferon-beta-inducing Traf family member-associated NF-kappa-B activator (TANK)-binding kinase-1."Proc. Natl. Acad. Sci. U.S.A. 102:13640-13645(2005) [PubMed] [Europe PMC] [Abstract]
  18. "RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival."Cell 127:157-170(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes."EMBO J. 26:3451-3462(2007) [PubMed] [Europe PMC] [Abstract]
  20. "The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response."EMBO J. 27:2135-2146(2008) [PubMed] [Europe PMC] [Abstract]
  21. "The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response."EMBO Rep. 9:930-936(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  23. "The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling."J. Biol. Chem. 284:19122-19131(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1."J. Virol. 83:3069-3077(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  26. "The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon."Nat. Immunol. 10:744-752(2009) [PubMed] [Europe PMC] [Abstract]
  27. "ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response."Proc. Natl. Acad. Sci. U.S.A. 106:7945-7950(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1."Immunity 33:878-889(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection."PLoS Pathog. 6:E1000778-E1000778(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  31. "Copy number variations on chromosome 12q14 in patients with normal tension glaucoma."Hum. Mol. Genet. 20:2482-2494(2011) [PubMed] [Europe PMC] [Abstract]
  32. "Mapping a dynamic innate immunity protein interaction network regulating type I interferon production."Immunity 35:426-440(2011) [PubMed] [Europe PMC] [Abstract]
  33. "IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1."J. Immunol. 187:2559-2568(2011) [PubMed] [Europe PMC] [Abstract]
  34. "TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I."J. Immunol. 186:3023-3030(2011) [PubMed] [Europe PMC] [Abstract]
  35. "Functional dissection of the TBK1 molecular network."PLoS ONE 6:E23971-E23971(2011) [PubMed] [Europe PMC] [Abstract]
  36. "IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 108:6474-6479(2011) [PubMed] [Europe PMC] [Abstract]
  37. "Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth."Science 333:228-233(2011) [PubMed] [Europe PMC] [Abstract]
  38. "Emerging roles for the non-canonical IKKs in cancer."Oncogene 30:631-641(2011) [PubMed] [Europe PMC] [Abstract]
  39. "Novel cross-talk within the IKK family controls innate immunity."Biochem. J. 434:93-104(2011) [PubMed] [Europe PMC] [Abstract]
  40. "PPM1B negatively regulates antiviral response via dephosphorylating TBK1."Cell. Signal. 24:2197-2204(2012) [PubMed] [Europe PMC] [Abstract]
  41. "Confirmation of TBK1 duplication in normal tension glaucoma."Exp. Eye Res. 96:178-180(2012) [PubMed] [Europe PMC] [Abstract]
  42. "TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1."J. Exp. Med. 209:1703-1711(2012) [PubMed] [Europe PMC] [Abstract]
  43. "NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4."Nat. Immunol. 13:387-395(2012) [PubMed] [Europe PMC] [Abstract]
  44. "Crystal structure and mechanism of activation of TANK-binding kinase 1."Cell Rep. 3:734-746(2013) [PubMed] [Europe PMC] [Abstract]
  45. "Structure and ubiquitination-dependent activation of TANK-binding kinase 1."Cell Rep. 3:747-758(2013) [PubMed] [Europe PMC] [Abstract]
  46. "Structural insights into the functions of TBK1 in innate antimicrobial immunity."Structure 21:1137-1148(2013) [PubMed] [Europe PMC] [Abstract]
  47. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]